Neuroimaging of Opioid Phase (OPAL)
Start Date
6/1/2023
Completion Date
6/30/2027
Summary
The purpose of this study is to compare activity in the brains of female adults with chronic pain and/or opioid use, and healthy female adults that may help to develop new and targeted treatments for adults with chronic pain and alternatives to opioid therapy.
Detailed Description
The objective of the study is to determine differences in neurophysiology and behavior during different phases of opioid use in patients. Study activities will include neuroimaging (MRI and fMRI), behavioral tasks, sensory testing, blood draws, and questionnaires. The neuroimaging data will be analyzed using specialized software; data from questionnaires, sensory testing, and behavioral task performance will be analyzed using standard statistical software. Risks and safety concerns include standard, minimal risks associated with MRI scans, sensory testing, blood draws, and confidentiality.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Opioid Phase
Conditions
Locations
Duke University Medical Center
Durham, North Carolina 27710
United States