NCT05932745NARecruiting

Effects of Novel E-cigarette Constituents on Adults TCORS 3.0

Yale University

Start Date

6/20/2025

Completion Date

8/1/2026

Summary

This study is an examination of the influence of cooling components of WS-3, WS-23, and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults.

Detailed Description

The investigators will examine the influence of cooling components of WS-3, WS-23 (synthetic coolants) and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults. Participants will rate the flavor intensity, coolness, sweetness, and irritation/harshness, bitterness experienced using validated rating scales. 66 adult participants (18+ years of age) who are current e-cigarette users will participate in 3 laboratory sessions. Participants will be randomized to receive one of the 3 menthol conditions (no-menthol, low menthol, high menthol) in Lab 1 and will receive the alternative conditions in randomized order in Lab 2 and Lab 3. During each lab session the menthol condition will be paired with three WS-3 concentrations: no WS-3, low (0.1%) WS-3, or high (2.0%) WS-3 and three WS-23 concentrations: low (0.1%) WS-23, high (2.0%) WS-23, or 4% WS-23 in randomized order. All e-cigarettes will contain nicotine salt at a nicotine concentration of \~59mg/ml and all participants will be exposed to eighteen conditions across 3 lab sessions.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * 18 years or older * Able to read and write * Some current e-cigarette use * Urine cotinine ≥200ng/ml * Willing to abstain from tobacco/nicotine use 2 hours prior to sessions Exclusion Criteria: * Current use of non-prescription substances besides nicotine, marijuana, alcohol * Any significant current medical or psychiatric condition * Known hypersensitivity to propylene glycol * Pregnant or lactating females * Uncontrolled asthma * Nut/e-liquid flavorant allergy * Current marijuana (tetrahydrocannabinol) vaping + E-cigarette or vaping use Associated Lung Injury (EVALI) symptoms * Dislike of menthol flavor

Interventions

OTHER

E-liquid coolant (No WS-3) for non-menthol (1)

OTHER

E-liquid coolant (No WS-3) for low (0.1%) menthol (1)

OTHER

E-liquid coolant (No WS-3) for high (2.0%) menthol (1)

OTHER

E-liquid coolant (Low [0.1%] WS-3) for non-menthol (2)

OTHER

E-liquid coolant (Low [0.1%] WS-3) for low (0.1%) menthol (2)

OTHER

E-liquid coolant (Low [0.1%] WS-3) for high (2.0%) menthol (2)

OTHER

E-liquid coolant (High [2.0%] WS-3) for non-menthol (3)

OTHER

E-liquid coolant (High [2.0%] WS-3) for low (0.1%) menthol (3)

OTHER

E-liquid coolant (High [2.0%] WS-3) for high (2.0%) menthol (3)

OTHER

E-liquid coolant (Low [0.1%] WS-23) for non-menthol (4)

OTHER

E-liquid coolant (Low [0.1%] WS-23) for low (0.1%) menthol (4)

OTHER

E-liquid coolant (Low [0.1%] WS-23) for high (2.0%) menthol (4)

OTHER

E-liquid coolant (High [2.0%] WS-23) for non-menthol (5)

OTHER

E-liquid coolant (High [2.0%] WS-23) for low (0.1%) menthol (5)

OTHER

E-liquid coolant (High [2.0%] WS-23) for high (2.0%) menthol (5)

OTHER

E-liquid coolant (4% WS-23) for non-menthol (6)

OTHER

E-liquid coolant (4% WS-23) for low (0.1%) menthol (6)

OTHER

E-liquid coolant (4% WS-23) for high (2.0%) menthol (6)

Interested in This Trial?

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Conditions

Nicotine Use Disorder

Locations

JB Pierce Lab

New Haven, Connecticut 06519

United States