NCT05938543NARecruiting

Cerebellar TMS and Satiety in Prader-Willi Syndrome

Brigham and Women's Hospital

Start Date

9/1/2023

Completion Date

10/1/2026

Summary

This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study hyperphagia and satiety in Prader-Willi syndrome. TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to the scalp. In this study, the investigators will be stimulating the brain to learn more about how TMS might improve hyperphagia in Prader-Willi syndrome.

Eligibility Criteria

Age Range: 18 years to 64 years

Inclusion Criteria: * Diagnosis of Prader-Willi syndrome Exclusion Criteria: * contraindications for TMS or MRI including : * history of neurological disorder * history of head trauma resulting in loss of consciousness * history of seizures or diagnosis of epilepsy or first degree relative family history of epilepsy * metal in brain or skull * implanted devices such as a pacemaker, medication pump, nerve stimulator or ventriculoperitoneal shunt claustrophobic in MRI

Interventions

DEVICE

Repetitive Transcranial Magnetic Stimulation (rTMS)

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Conditions

Prader-Willi Syndrome

Locations

McLean Hospital

Belmont, Massachusetts 02478

United States