NCT05962424PHASE1Recruiting

HNC: Human Neural Circuits Electrophysiology During Cognition

Stanford University

Start Date

10/5/2023

Completion Date

9/1/2030

Summary

The purpose of this study is to understand how ketamine brings about dissociative symptoms.

Detailed Description

The goal of this proposed research is to record the effects of ketamine on brain activity to understand the changes that occur during antidepressant therapy and the side effect of dissociation. This research is designed to probe altered cognitive states associated with dissociation, depression, and other neuropsychiatric conditions.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Patient in clinical neuro inpatient units at Stanford Medical Center * Age \>18 years old * Female participants are expected to use an effective method of birth control throughout the study which includes: hormonal methods (birth control pills, patches, injections, vaginal ring or implants), barrier methods (condom or diaphragm) used with spermicide, intrauterine device (IUD), or abstinence (no sex) Exclusion Criteria: * Lifetime psychotic disorder * Pregnant or nursing females * Prior adverse ketamine response * Use of ketamine in past 7 days

Interventions

DRUG

Ketamine Hydrochloride

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Conditions

Psychiatric Disorder

Locations

Stanford University

Palo Alto, California 94306

United States