NCT05975593NARecruiting
MicroEnvironment Tumor Effects of Radiotherapy - Comprehensive Radiobiology Assessment TRial
Washington University School of Medicine
Start Date
1/11/2024
Completion Date
12/31/2032
Summary
This study is a dynamically adjustable prospective longitudinal study designed to capture biospecimen (biopsy, blood, surgical) and multimodal treatment-related data (imaging, dosimetry, clinical) before, during, and after treatment with definitive-intent chemoradiotherapy for patients with locally advanced cervical and pancreatic cancer.
Eligibility Criteria
Age Range: 18 years to No maximum
Inclusion Criteria:
* Confirmation of intent to receive radiotherapy for one of the following diagnoses:
* Cervical cancer
* Pancreatic cancer
* ECOG performance status ≤ 2
* At least 18 years old
* Able to understand and willing to sign an IRB-approved written informed consent document
Exclusion Criteria:
* Any issue (medical, anatomic, other) that might preclude safe acquisition of biospecimens at the discretion of the treating physician
Interventions
OTHER
Tumor collection via biopsy
OTHER
Blood collection
DEVICE
Diffusion basis spectrum imaging (DBSI) magnetic resonance imaging (MRI)
Conditions
Locally Advanced Cervical CarcinomaLocally Advanced Cervical CancerLocally Advanced Pancreas CancerLocally Advanced Pancreatic CarcinomaLocally Advanced Pancreatic CancerCervical CancerPancreas CancerPancreatic CancerCancer of the CervixCancer of the Pancreas
Locations
Washington University School of Medicine
St Louis, Missouri 63110
United States