Study Evaluating INS018_055 Administered Orally to Subjects With Idiopathic Pulmonary Fibrosis
Start Date
2/8/2024
Completion Date
2/28/2026
Summary
The purpose of this revised Phase IIa study is to demonstrate safety of INS018\_055 over 12 weeks in adults with Idiopathic Pulmonary Fibrosis (IPF).
Detailed Description
Idiopathic pulmonary fibrosis is a fatal lung disease characterized by reduced quality of life (QoL) and a median survival of 3 to 4 years. While current standard of care (SoC) treatments including pirfenidone and nintedanib slow disease progression, they are not curative and poorly tolerated due to their toxicity profiles. To address the need for new treatments in IPF, InSilico Medicine is developing INS018\_055, a potent inhibitor of the serine/threonine kinase Traf2- and Nckinteracting kinase (TNIK).
Eligibility Criteria
Age Range: 40 years to No maximum
Interventions
INS018_055
Placebo
Conditions
Locations
University of Alabama at Birmingham
Birmingham, Alabama 35294
United States
HonorHealth Research Institute
Scottsdale, Arizona 85258
United States
Keck School of Medicine of USC
Los Angeles, California 90033
United States
Florida Lung Asthma and Sleep Specialist
Celebration, Florida 34747-1818
United States
Central Florida Pulmonary Group, P.A. (CFPG) - Downtown Orlando
Orlando, Florida 32803-5727
United States
Southeastern Research Center
Winston-Salem, North Carolina 27103-4007
United States
University of Oklahoma Health Sciences Center (OUHSC)
Oklahoma City, Oklahoma 73104-5417
United States
Temple University Hospital-Temple Lung Center
Philadelphia, Pennsylvania 19140
United States
Bogan Sleep Consultants, LLC
Columbia, South Carolina 29201-2953
United States
University of Texas Southwestern Medical Center
Dallas, Texas 75235-6243
United States
Metroplex Pulmonary and Sleep Center
McKinney, Texas 75069-1898
United States
Research Centers of America
McKinney, Texas 75071
United States