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NCT06066710EARLY_PHASE1Recruiting

Propranolol in Primary Progressive Aphasia

University of Missouri-Columbia

Start Date

1/13/2025

Completion Date

12/1/2027

Summary

The purpose of this study is to find out how the language of people with Primary Progressive Aphasia is affected by Propranolol. Propranolol is not FDA approved for the treatment of Primary Progressive Aphasia. Propranolol is FDA approved for the treatment of heart conditions such as blood pressure. This research is being done because there are currently no drug treatment options for language impairments and anxiety often experienced by people with Primary Progressive Aphasia.

Eligibility Criteria

Age Range: 50 years to No maximum

Inclusion Criteria: * 1\. Age: 50 and older * 2\. Primary Progressive Aphasia diagnosis * 3\. Native English speaker Exclusion Criteria: * 1\. Unable to provide consent * 2\. Taking alpha 2 agonists (clonidine and guanfacine) * 3\. Other major psychological or neurological diagnosis * 4\. Major head trauma that contributed to their condition * 5\. Allergic reaction to adhesives * 6\. Uncorrected vision/hearing impairments * 7\. Diabetes * 8\. Reactive airway disease * 9\. Untreated hypothyroidism * 10\. Bradyarrhythmia * 11\. Unexplained syncope * 12\. Pregnancy (assessed verbally on the days of MR imaging) * 13\. Drugs that interact with propranolol, such as alpha 2 agonists * 14\. Claustrophobia, inner ear implants, aneurysm or other surgical clips, metal foreign bodies in eye, pacemaker or other contraindication to MR scanning. Subjects with any implanted device that cannot be verified as MRI compliant will be excluded.

Interventions

DRUG

Propranolol

DEVICE

Magnetic Resonance Imaging (MRI)

DRUG

Placebo

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Conditions

Aphasia, Primary Progressive

Locations

University of Missouri-Columbia

Columbia, Missouri 65212

United States