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NCT06072976NARecruiting

The Influence of Feeding Source on the Gut Microbiome and Time to Full Feeds in Neonates With Congenital Gastrointestinal Pathologies

Seattle Children's Hospital

Start Date

6/9/2023

Completion Date

6/9/2027

Summary

This study explores the use of an exclusive human milk diet versus standard feeding practices to compare the influence on feeding outcomes and the gut bacteria in infants with intestinal differences.

Eligibility Criteria

Age Range: No minimum to 55 years

Inclusion Criteria: * Infants with gastroschisis, giant omphalocele, intestinal atresia, mid-gut volvulus, hirschsprungs disease. Exclusion Criteria: 1. Infant has already been on feeds 2. Infants \<34 weeks gestation 3. Parents with contraindications to providing milk (i.e. drug use-cocaine, fentanyl, meth BUT oxy/suboxone/marijuana OK) 4. Complicated gastroschisis 5. Short gut syndrome 6. Additional congenital anomalies that affect ability to tolerate milk (i.e. cyanotic congenital heart disease BUT kidney disease ok)

Interventions

DIETARY_SUPPLEMENT

Standard of Care

DIETARY_SUPPLEMENT

Exclusive Human Milk

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Conditions

Gastrointestinal ComplicationIntestinal ObstructionGastroschisisHirschsprung DiseaseOmphaloceleMidgut Volvulus

Locations

Seattle Children's Hospital

Seattle, Washington 98105

United States