NCT06080347NARecruiting
Effect of Anti-inflammatory Diet in Osteoarthritis
University of California, San Diego
Start Date
10/1/2023
Completion Date
1/1/2026
Summary
In a previous exploratory study, the investigators observed an effect on disease activity outcomes of anti-inflammatory diet. The investigators also observed change in microbiome and circulating metabolites. The current study will determine whether or not the addition of anti-inflammatory diet improves the clinical outcomes in participants with Osteoarthritis, and the role of microbiome and circulating metabolites.
Eligibility Criteria
Age Range: 18 years to No maximum
Inclusion Criteria:
* Unilateral radiographic symptomatic KOA
* No changes in therapy during the previous 3 months
* Interested in dietary intervention and able to provide consent and attend follow-up visits
Exclusion Criteria:
* Previous knee surgery
* Severe radiographic disease (KL grade 4)
* Rheumatoid Arthritis
* Any Abnormal blood values in the comprehensive metabolic panel test at screen (Abnormality will be defined based on standard reference ranges)
* Use of corticosteroids and/or intra-articular injections during the preceding 3 months
* Use of fish oils and glucosamine
* Participation in a weight loss program in the preceding 6 months
* Recent changes in physical activity levels
* Regular smoking
* Patients with food allergies
* Patient with other medical conditions that will impair the ability to participate in a nutritional study
* Plan to change systemic therapy
* Patients unwilling to change dietary habits
Interventions
OTHER
Anti-inflammatory Diet
OTHER
Healthy Diet
Conditions
Osteoarthritis, Knee
Locations
University of California
San Diego, California 92122
United States