Apathy in Parkinson Disease TMS Study
Start Date
5/1/2024
Completion Date
6/30/2027
Summary
The goal of this clinical trial is to develop non-invasive brain stimulation targets for the treatment of apathy, or motivation problems, in Parkinson Disease. The main questions the study aims to answer are: 1. Does transcranial magnetic stimulation change effort task performance in Parkinson's Disease patients? 2. Is there a link between brain signals and apathy? Participants will * complete questionnaires and assessments * perform an effort task * have their brain activity recorded (EEG) * receive non-invasive brain stimulation (TMS) Researchers will compare two stimulation locations (experimental site and control site) to see if TMS of the experimental site has an effect on apathy. Participants will receive stimulation of both sites (during separate visits).
Detailed Description
Participants will be asked to come for 3 study visits. During visit 1, after being informed about the study and potential risks, all patients giving written informed consent will undergo a brief cognitive assessment, a movement examination, and answer questionnaires. Additionally, the individual motor threshold will be determined for each participant. Visit 1 will take 2-3 hours. Visits 2 and 3 will involve: * completing questionnaires, * performing a task where fictitious rewards can be earned by squeezing a dynamometer, * recording brain activity with an electroencephalogram (EEG), and * receiving transcranial magnetic stimulation (TMS). Visits 2 and 3 will take approximately 3 hours each and will be separated from each other by at least 3 weeks.
Eligibility Criteria
Age Range: 55 years to 80 years
Interventions
Transcranial Magnetic Stimulation (TMS)
Conditions
Locations
UNC-Chapel Hill, Cassidy Lab
Chapel Hill, North Carolina 27599
United States