NCT06088758NARecruiting

Normothermic Machine Perfusion of Steatotic Livers for Expansion of Donor Organ Pool

Massachusetts General Hospital

Start Date

2/28/2024

Completion Date

7/31/2027

Summary

The goal of this clinical trial is to assess the ability of Normothermic Machine Perfusion (NMP) to resuscitate moderately steatotic livers for transplantation in patients. This will be a single-site clinical trial placing donor livers with 30-60% macrosteatosis on NMP, and then transplanting those that meet commonly accepted viability criteria. The results of this study could lead to a trial extending NMP transplantation to severely steatotic livers, further expanding the donor organ pool.

Eligibility Criteria

Age Range: 18 years to 80 years

Inclusion Criteria: * Age 18-80 years * Listed for liver transplantation at MGH * Calculated MELD-Na score \<= 25 * Able to consent Exclusion Criteria: * Status 1a * Cardiac or pulmonary disease * Prior liver transplant * Requiring pressors at the time of liver offer * MELD\<15 and asymptomatic from liver disease

Interventions

DEVICE

Normothermic machine perfusion (NMP) of steatotic liver

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Conditions

Liver Transplant

Locations

Massachusetts General Brigham

Boston, Massachusetts 02114

United States