A Study to Assess BMS-986458 Alone and in Combination With Anti-lymphoma Agents in Relapsed/Refractory Non-Hodgkin Lymphomas
Start Date
12/29/2023
Completion Date
10/28/2028
Summary
The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary biological and clinical activity of BMS-986458, a bifunctional cereblon-dependent ligand-directed degrader of B-cell lymphoma 6 (BCL6), as a single agent and in combination with anti-lymphoma agents in participants with relapsed/refractory non-Hodgkin Lymphoma.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
BMS-986458
Rituximab
Glofitamab/Obinutuzumab
Mosunetuzumab
Epcoritamab
Golcadomide
Conditions
Locations
Mayo Clinic in Arizona - Phoenix
Phoenix, Arizona 85054
United States
City of Hope Comprehensive Cancer Center
Duarte, California 91010
United States
Local Institution - 0068
Jacksonville, Florida 32224
United States
Moffitt Cancer Center
Tampa, Florida 33612
United States
Dana-Farber Cancer Institute
Boston, Massachusetts 02215
United States
Mayo Clinic in Rochester, Minnesota
Rochester, Minnesota 55905
United States
Local Institution - 0124
Omaha, Nebraska 68105
United States
Local Institution - 0047
Lake Success, New York 11042
United States
Local Institution - 0037
New York, New York 10016
United States
Memorial Sloan Kettering Cancer Center
New York, New York 10065
United States
Local Institution - 0045
Providence, Rhode Island 02903
United States
Local Institution - 0118
Antofagasta, AN 1240000
Chile
Local Institution - 0105
Santiago, Metropolitana de Santiago 7580206
Chile
Local Institution - 0109
Santiago, Santiago Metropolitan 8420383
Chile
Beijing Cancer hospital
Beijing, Beijing Municipality 100142
China
Local Institution - 0084
Guangzhou, Guangdong 510555
China
Local Institution - 0087
Zhengzhou, Henan 450008
China
Local Institution - 0089
Nanchang, Jiangxi 330006
China
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest
Bordeaux, Aquitaine 33076
France
Local Institution - 0125
Lyon, Nan 69373
France
Hopital Claude Huriez - CHU de Lille
Lille, Nord 59000
France
Gustave Roussy
Villejuif, Paris 94800
France
Henri Mondor Hospital
Créteil, Val-de-Marne 94010
France
CHU SAINT ELOI - Departement Hematologie Clinique
Montpellier, 34295
France
Hôpital Saint-Louis
Paris, 75010
France
Institut Claudius Regaud
Toulouse, 31059
France
Universitätsklinikum Münster - Albert Schweitzer Campus
Münster, North Rhine-Westphalia 48149
Germany
Universitaetsklinikum des Saarlandes
Homburg, Saarland 66424
Germany
Universitätsklinikum Leipzig
Leipzig, Saxony 04103
Germany
Helios Klinikum Berlin-Buch
Berlin, 13125
Germany
Local Institution - 0070
Essen, 45147
Germany
Local Institution - 0103
Pátrai, Achaḯa 26504
Greece
Local Institution - 0106
Alexandroupoli, Evros 68100
Greece
Local Institution - 0107
Athens, 10676
Greece
Local Institution - 0102
Athens, 11 527
Greece
Local Institution - 0119
Hong Kong, 0
Hong Kong
Local Institution - 0094
Bologna, 40138
Italy
Local Institution - 0116
Brescia, 25123
Italy
Local Institution - 0098
Milan, 20132
Italy
Local Institution - 0113
Milan, 20133
Italy
Local Institution - 0112
Pisa, 56126
Italy
Local Institution - 0111
Ravenna, 48121
Italy
Local Institution - 0115
Roma, 00144
Italy
Local Institution - 0110
Roma, 00168
Italy
Local Institution - 0097
Verona, 37134
Italy
Local Institution - 0090
Nagoya, Aichi-ken 4668560
Japan
Local Institution - 0091
Chuo-ku, Tokyo 104-0045
Japan
Local Institution - 0086
Chūō, Yamanashi 4093898
Japan
Local Institution - 0092
Fukuoka, 812-8582
Japan
Maastricht UMC+
Maastricht, Limburg 6229 HX
Netherlands
Local Institution - 0121
Amsterdam, North Holland 1981 HV
Netherlands
University Medical Center Groningen
Groningen, 9713 GZ
Netherlands
Local Institution - 0123
Seoul, Seoul Teugbyeolsi 03080
South Korea
Local Institution - 0077
Seoul, Seoul Teugbyeolsi 06351
South Korea
Local Institution - 0078
Seoul, Seoul-teukbyeolsi 05505
South Korea
Hospital Universitario Virgen de la Victoria
Málaga, Andalusia 29010
Spain
Hospital Universitari Vall d'Hebron
Barcelona, Barcelona [Barcelona] 08035
Spain
Hospital General Universitario Gregorio Marañon
Madrid, Madrid, Comunidad de 28009
Spain
Clinica Universidad de Navarra
Pamplona, Navarre 31008
Spain
Hospital Universitario Fundación Jiménez Díaz
Madrid, 28040
Spain
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca
Salamanca, 37007
Spain
Ospedale Regionale Bellinzona e Valli
Bellinzona, Canton Ticino 6500
Switzerland
University Hospital Basel
Basel, 4031
Switzerland
Hopitaux Universitaires de Geneve (HUG)
Geneva, 1205
Switzerland
Local Institution - 0071
Southampton, Hampshire SO16 0YD
United Kingdom
Local Institution - 0081
Manchester, Lancashire M20 4BX
United Kingdom
Local Institution - 0072
Edinburgh, Midlothian EH4 2XU
United Kingdom