Dupilumab De-escalation in Pediatric Atopic Dermatitis
Start Date
4/1/2024
Completion Date
4/30/2027
Summary
This is a pilot investigator-blinded, randomized clinical trial to assess the feasibility of dupilumab treatment discontinuation or dose-reduction in children aged 1-17 years who have achieved sustained atopic dermatitis (AD) control on dupilumab.
Detailed Description
Participants will be randomly assigned to one of three groups: discontinuation of dupilumab; reduction of dupilumab dose; or continuation of standard dupilumab dose. During the active study treatment period, participants will be asked to complete 5 study visits. At these visits, a physician will conduct a skin examination to assess atopic dermatitis (AD) severity and participants will complete questionnaires about their AD symptoms and severity. During the observational period, participants will be asked to complete questionnaires about their AD symptoms and medication use every twelve weeks, for a total of 3 follow-up contacts. The purpose of this study is to evaluate the feasibility and sustainability of reducing or discontinuing dupilumab in children with well-controlled AD.
Eligibility Criteria
Age Range: 1 years to 17 years
Interventions
Dupilumab - Discontinuation
Dupilumab - Dose Reduction
Dupilumab - Standard Dose
Conditions
Locations
Johns Hopkins Univerisity
Baltimore, Maryland 21210
United States