The Role of Neutrophils in the Age-driven Decline in Anti-pneumococcal Vaccine Responses

Summary

This study focuses on the role of neutrophils in shaping the adaptive immune response to the anti-pneumococcal vaccine Prevnar-13 in young and elderly adults.

Detailed Description

This study focuses on the role of neutrophils in shaping the adaptive immune response to the anti-pneumococcal vaccine Prevnar in young and elderly adults. This study involves direct vaccination of human volunteers. The endpoints will be determining how vaccination affects neutrophil responses and linking those neutrophil responses to antibody responses following vaccination. The main results will be: 1. Elucidating how neutrophils kill bacteria before and after vaccination 2. Elucidate the phenotype of neutrophils before and after vaccination 3. Elucidate how neutrophils interact with B and T cell in vitro before and after vaccination 4. Measure antibody levels and function before and after vaccination 5. Correlate neutrophil responses to antibody levels and function

Eligibility Criteria

Interventions