NCT06137339NARecruitingAccepts Healthy Volunteers
AvoCog - the Effect of Daily Avocado Intake on Cognitive Function in Older Adults
University of Kansas Medical Center
Start Date
4/9/2024
Completion Date
12/1/2025
Summary
The goal of this clinical trial is to determine if adding avocados to the diet of impacts cognition in 70 older adults, age 65-85, without dementia. We will test for change in functional MRI, cognitive performance, and brain blood flow. Intervention group participants will be asked to consume 1 avocado per day for 12 weeks. Participants in the control group will be asked to continue their normal intake for 12 weeks. Throughout the study, participants will be asked to perform cognitive tests, MRI, blood tests, and questionnaires.
Eligibility Criteria
Age Range: 65 years to 85 years
Inclusion Criteria:
* Males and females aged 65-85 years
* Good general health with no concomitant disease
* BMI 18.5 - 35 kg/m2
* Mini Mental State Exam ≥26
* Reports consuming ≤2 medium avocados per month
* Reports consuming ≤3 servings of carotenoid-rich foods per week and ≤3 servings of fruits and vegetables per day
* Skin carotenoid content \<400
Exclusion Criteria:
* Unwilling or unable to consume avocado
* Latex allergy
* Consistently taking lutein + zeaxanthin supplements
* Skin carotenoid content ≥400
* Central neurological disease such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, brain tumor, etc.
* Serious medical risk: cancer requiring chemotherapy or radiation within the past 5 years, recent cardiac event (i.e. heart attack, etc.)
* Diabetes mellitus or uncontrolled hypertension
* Use of psychoactive or investigational medications
* Consumption of ≥3 alcoholic drinks per day or substance abuse
* Unable to undergo MRI
Interventions
OTHER
Avocado Group
Conditions
Brain Aging
Locations
University of Kansas Medical Center
Kansas City, Kansas 66160
United States