NCT06150560PHASE3Recruiting

A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)

Mayo Clinic

Start Date

4/1/2024

Completion Date

6/1/2028

Summary

The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * B/S1 hypertension * SBP 100-139 average based on 3 office measurements. * Age 18 or Older * Previous COA Repair Exclusion Criteria: * Currently on beta blocker (BB) therapy * Pregnancy/lactating * eGFR\<30 * Hyperkalemia (serum potassium \>5.5mmol/L) * Severe Aortic or Mitral valve stenosis or regurgitation * Epicardial CAD diagnosis * Received antihypertensive medications within the past year

Interventions

DRUG

Losartan

DRUG

Amlodipine

DRUG

Placebo

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Conditions

Coarctation of AortaHigh Blood Pressure

Locations

Mayo Clinic in Rochester

Rochester, Minnesota 55905

United States