NCT06165419PHASE2Recruiting
Definitive Radiation for High-Risk Spine Metastases
Stony Brook University
Start Date
12/14/2023
Completion Date
5/31/2026
Summary
This study is looking at whether patients with cancer that has aggressively spread to the spine can be treated with stereotactic body radiation therapy only and avoid a large spine surgery
Eligibility Criteria
Age Range: 18 years to No maximum
Eligible patients must have:
* Any pathologically proven solid tumor diagnosis not of central nervous system origin with radiographic or pathologic evidence of metastatic disease
* Metastatic spine involvement documented by imaging
* Involvement of maximum 3 contiguous vertebral bodies at the index site
* Intact neurologic function, or only minor neurologic deficits with muscle strength greater or equal to 4 out of 5 with or without steroids
* An evaluation by an radiation oncology and orthopedic spine/neurosurgery attending
* ECOG Performance Status of 0-3
Patients are ineligible if they have:
* An unstable spine defined as a Spinal Instability Neoplastic Score (SINS) greater than 12
* Had previous surgery or radiation to address the target spinal metastases
* Radiosensitive tumors (e.g. small cell lung cancer, lymphoma, multiple myeloma, and germ-cell tumors)
Interventions
RADIATION
SBRT to the spine
Conditions
Metastatic CancerMetastatic Lung CancerMetastatic Breast CancerMetastatic TumorMetastatic Tumor of BoneMetastatic Tumor to the SpineSpine MetastasesMetastasis
Locations
Stony Brook University Hospital
Stony Brook, New York 11794
United States