ADAPT Study: Assessing Diet, Appetite and Physiology Throughout Weight Loss Study)
Start Date
10/1/2023
Completion Date
7/31/2027
Summary
Behavioral weight loss programs for obesity can result in weight loss and health benefits. However, behavioral weight loss often stops despite efforts to continue losing weight, this can be called an involuntarily weight loss plateau. This study investigates changes in metabolism and/or the brain that contribute to the occurrence of an involuntary weight loss plateau.
Detailed Description
Participants will be asked to enroll for 18-months. Each participant will complete 3 in-person study visits, then participate an a 6-month weight loss program delivered remotely. Some participants may be invited to complete 3 additional in-person visits. Study Visit activities include questionnaires, blood draws, brain MRIs, body measurement and dual energy x-ray absorptiometry (DXA) scan for body composition measurement, a breathing test, and biopsies of muscle and fat tissue. Each participant will be provided a fitness tracker and body weight scale to use throughout the study.
Eligibility Criteria
Age Range: 18 years to 60 years
Interventions
Behavioral Weight Loss Program
Conditions
Locations
Fred Hutch Cancer Center
Seattle, Washington 98109
United States
University of Washington - South Lake Union
Seattle, Washington 98109
United States