Back to Trials
NCT06212791Recruiting

EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation

Virginia Commonwealth University

Start Date

12/26/2024

Completion Date

3/1/2028

Summary

Longitudinal, observational cohort study to evaluate changes in left atrial (LA) reservoir function during exercise and overall exertional capacity in patients following catheter ablation for paroxysmal atrial fibrillation (AF).

Detailed Description

EXCLAMATORY is a longitudinal observational cohort clinical research study to evaluate the effects of catheter ablation for paroxysmal atrial fibrillation on left atrial and left ventricular performance during exercise, as well as effects on overall exercise capacity

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Age ≥18 years * Diagnosis of paroxysmal AF * Left ventricular ejection fraction ≥50% * Scheduled for catheter ablation * Able to speak, hear, and read English * Willing and able to provide informed consent Exclusion Criteria: * Persistent or permanent AF * Prior ablation (catheter based or surgical) for AF * Significant sinus node dysfunction * Implanted pacemaker or defibrillator * Contraindication to or inability to complete cardiovascular magnetic resonance study * Contraindication to or inability to complete exercise testing * Chronic kidney disease with estimated glomerular filtration rate \<30 mL/min/1.73m2 * Severe left ventricular hypertrophy * Unrelated cardiomyopathy that is expected to limit exercise capacity, including but not limited to: * Hypertrophic cardiomyopathy * Cardiac amyloidosis * Constrictive pericarditis * Pulmonary arterial hypertension * Prior cardiac surgery * Active pregnancy

Interventions

BEHAVIORAL

Self- Report Evaluation-Duke Activity Status Index

BEHAVIORAL

Self- Report Evaluation Atrial Fibrillation Effect on Quality of Life Questionnaire

DIAGNOSTIC_TEST

Cardiopulmonary exercise test (CPET)

DIAGNOSTIC_TEST

Transthoracic echocardiogram

DIAGNOSTIC_TEST

Ambulatory cardiac rhythm assessment

DIAGNOSTIC_TEST

Cardiovascular magnetic resonance (CMR)

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

Paroxysmal Atrial Fibrillation

Locations

Virginia Commonwealth University

Richmond, Virginia 23298

United States