NCT06229860Recruiting

Impact of Personality on Adherence to Tyrosine Kinase Inhibitor Therapy in Pts w/Chronic Myeloid Leukemia

University of California, Irvine

Start Date

1/25/2024

Completion Date

12/1/2026

Summary

This is an observational pilot study to examine the association between a patient's personality and adherence to tyrosine kinase inhibitor therapy in patients with chronic myeloid leukemia.

Detailed Description

The purpose of this pilot study is to explore the association between personality and adherence to a specific type of oral cancer medication - tyrosine kinase inhibitor (TKI) - in patients with chronic myeloid leukemia (CML). 75 individuals with chronic phase CML who are being treated with TKIs will be recruited. Consenting patients will participate in a focused interview where TKI adherence, personality type, and quality of life and symptom burden will be assessed using validated questionnaires. Information on treatment response and the treating physician's perception of TKI adherence will be obtained from the electronic health record.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * 18 years of age or older * Diagnosed with chronic myeloid leukemia (CML) and in the chronic phase (CML-CP) * Currently being treated with one of four cancer medications - imatinib, dasatinib, bosutinib, or nilotinib * A patient at the UCI Chao Family Comprehensive Cancer Center (CFCCC), or * A member of a patient support group organized by the CML Buster Foundation * Do not meet any of the criteria listed under "Exclusion Requirements" Exclusion Criteria: * Unable to read and speak English * Impaired decisional capacity to consent

Interventions

OTHER

Interview

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Conditions

Chronic Myeloid LeukemiaChronic Phase Chronic Myelogenous Leukemia

Locations

Chao Family Comprehensive Cancer Center University of California, Irvine

Orange, California 92868

United States