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NCT06273748Recruiting

RChildUV:Study on Non-infectious Chronic Uveitis in Pediatric Age

Meyer Children's Hospital IRCCS

Start Date

2/10/2022

Completion Date

5/2/2032

Summary

Uveitis is an inflammatory disease of the uvea, one of the highly vascularized fundamental structures of the eye. It is a rare condition in children, with an incidence in the pediatric population ranging from 2% to 14% of all uveitis cases. The diagnosis and management of patients with uveitis rely on a multidisciplinary approach involving an ophthalmologist, a rheumatologist, and an infectious disease specialist to establish the correct diagnosis and assess the involvement of other organs. In Italy, there is no national or regional registry for non-infectious chronic uveitis as per the Prime Ministerial Decree (DPCM) of March 3, 2017 (Identification of surveillance systems and registries for mortality, tumors, and other diseases). However, many clinical centers adopt data recording systems to evaluate the quality of care and to study diseases and outcomes. The Universitary Hospital Meyer Institute Research Hospital (IRCCS) is a national referral center for managing these pediatric cases of non-infectious chronic uveitis, estimated to constitute 95% of all pediatric uveitis cases

Eligibility Criteria

Age Range: 1 years to 16 years

Inclusion Criteria: * diagnosis of non-infectious chronic uveitis before the age of 16; * signed informed consent form. Exclusion Criteria: * Patients with a diagnosis of infectious uveitis * history of malignant pathology, * history of demyelinating pathology, * history of cerebral vasculitis

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Conditions

Uveitis

Locations

Children's Mercy Kansas City Division of Rheumatology, Division of Rheumatology

Kansas City, Kansas 64108

United States

The Children's Hospital Corporation d/b/a Boston Children's Hospital

Boston, Massachusetts 02115

United States

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio 45207

United States

University fo Gent

Ghent,

Belgium

ATTIKON General Hospital

Athens, 12462

Greece

Meyer Children's Hospital IRCCS

Florence, Firenze

Italy

Department of Pediatrics, Giovanni XXIII Pediatric Hospital, University of Bari

Bari,

Italy

Ospedale Spedali Civili di Brescia

Brescia,

Italy

Department of Medical of Health Sciences, Magna Grecia University

Catanzaro,

Italy

Dipartimento di Immunologia e Reumatologia Pediatrica, Ospedale Vito Fazzi

Lecce,

Italy

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico SC Pediatria e Immunoreumatologia PI

Milan,

Italy

Unità di Reumatologia ed Immunologia Pediatrica dell'Ospedale Fatebenefratelli Sacco di Milano

Milan,

Italy

- UOSD Reumatologia Pediatrica Dipartimento di Salute della Donna e del Bambino Azienda Ospedale Università di Padova

Padova,

Italy

Clinica Pediatrica, IRCCS Policlinico San Matteo

Pavia,

Italy

IRCCS Ospedale Pediatrico Bambino Gesù Dipartimento Reumatologia

Roma,

Italy

Santa Maria Goretti Hospital

Roma,

Italy

Unità di Immunologia e Reumatologia, Ospedale Pediatrico Regina Margherita, AOU Città della Salute e della scienza di Torino

Torino,

Italy

IRCCS materno infantile Burlo Garofolo

Trieste,

Italy

Department of Pediatric Rheumatology, Kocaeli University,

Kocaeli,

Turkey (Türkiye)