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NCT06277037Recruiting

Long-Term Follow-up Study for Subjects With CHB Previously Treated With Imdusiran (AB729)

Arbutus Biopharma Corporation

Start Date

7/11/2024

Completion Date

10/30/2029

Summary

This is a long term follow-up study for chronic hepatitis B (CHB) subjects who have received imdusiran treatment in a prior clinical trial, stopped NA therapy during that trial, and remain off therapy. Subjects may enroll after completing the end of study visit (baseline visit within 12 weeks ± 1 week from the end of study \[EOS\] visit) from their imdusiran clinical trial (the "parent study"). No interventions will be performed in this study other than blood sample collections, review of current medications, and reporting of any adverse events related to study procedures or NA therapy if restarted. Study participation will be for approximately 2 years (to complete a total of at least 3 years of follow-up while off NA therapy, inclusive of parent study participation).

Eligibility Criteria

Age Range: 20 years to 70 years

Key Inclusion Criteria: * Have participated in a prior imdusiran clinical trial, * Have discontinued NA therapy in that trial and remain off NA therapy, * Have completed less than 3 years of follow-up visits after NA discontinuation in the parent study. * Have the ability to review and provide signed informed consent which includes compliance with all protocol-specified visit schedules and requirements. Exclusion Criteria: * Not applicable

Interventions

OTHER

Non-interventional

Interested in This Trial?

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Conditions

Long Term Follow-up

Locations

Research and Education Inc.

San Diego, California 92105

United States

University of Miami Miller School of Medicine

Miami, Florida 33136

United States

Infectious Disease Care

Hillsborough, New Jersey 08844

United States

The Alfred Hospital

Melbourne, Victoria 3004

Australia

Fiona Stanley Hospital

Murdoch, 6150

Australia

Prince of Wales Hospital

Shatin, New Territories

Hong Kong

Queen Mary Hospital

Hong Kong,

Hong Kong

Arensia Exploratory Medicine Moldova

Chisinau,

Moldova

Asan Medial Center

Seoul, 05505

South Korea

Changhua Christian Hospital

Changhua, 600566

Taiwan

Chia-Yi Christian Hospital

Chiayi City, 60002

Taiwan

Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, 80756

Taiwan

E-Da Hospital

Kaohsiung City, 82445

Taiwan

Taichung Veterans General Hospital

Taichung, 40705

Taiwan

Chang Gung Medical Foundation Linkou

Taoyuan, 33305

Taiwan

University Hospital of Wales, Cardiff

Cardiff, CF144XW

United Kingdom

Royal London Hospital

London, E11FR

United Kingdom

King's College Hospital

London, SE59RS

United Kingdom