NCT06296810Recruiting

Adaptive DBS to Offset STN Dysregulation During Exercise in PD

University of Colorado, Denver

Start Date

9/1/2024

Completion Date

12/1/2025

Summary

The investigators conduct a prospective study to evaluate the effects of exercise on Parkinson's Disease brain biomarkers detected with the PerceptTM PC neurostimulator.

Detailed Description

The investigators will conduct a prospective study to evaluate the effects of exercise on Local Field Potential biomarkers detected from the subthalmic nuclues in Parkinson's Disease with the PerceptTM PC neurostimulator. Subsequently, adaptive Deep Brain Stimulation applied in response to low beta peak (L-beta; 13-20Hz) will be performed to evaluate feasibility of whether aDBS can offset the effects of exacerbation of parkinsonism during exercise performance and recovery.

Eligibility Criteria

Age Range: 20 years to 70 years

Inclusion Criteria: Persons with PD who have a Medtronic DBS Sensight implant and a Percept IPG. \- Exclusion Criteria: Persons not meeting the above listed implant criteria Persons not meeting the age limit criteria Persons who are not able to complete the study exercise Persons not able to comprehend and consent to study participation.

Interventions

DEVICE

aDBS

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

Parkinson Disease

Locations

University of Colorado

Aurora, Colorado 80045

United States