NCT06333652PHASE2Recruiting
Ravulizumab in Pregnancies Complicated by Severe Hypertensive Disorders
Mayo Clinic
Start Date
9/1/2026
Completion Date
12/31/2028
Summary
The researchers are testing a medication named ravulizumab for the treatment of severe preeclampsia and Hemolysis, Elevated Liver enzymes, Low Platelets (HELLP) syndrome.
Eligibility Criteria
Age Range: 18 years to 50 years
Inclusion Criteria:
* Individuals with \< 34 0/7 weeks of gestation.
* Individuals with severe preeclampsia or HELLP features.
Exclusion Criteria:
* Pregnant female patients presenting with disseminated intravascular coagulopathy (DIC).
* Individuals with non-reassuring fetal status requiring delivery, non-viable fetuses, previable pregnancy (\<23 0/7 weeks gestation), stroke, in utero fetal demise, known atypical hemolytic uremic syndrome, familial or acquired thrombocytopenia purpura, paroxysmal nocturnal hemoglobinuria, allergy to Ravulizumab, inability or unwillingness to sign informed consent.
Interventions
DRUG
Ravulizumab
Conditions
Preeclampsia
Locations
Mayo Clinic Minnesota
Rochester, Minnesota 55905
United States