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NCT06333652PHASE2Recruiting

Ravulizumab in Pregnancies Complicated by Severe Hypertensive Disorders

Mayo Clinic

Start Date

9/1/2026

Completion Date

12/31/2028

Summary

The researchers are testing a medication named ravulizumab for the treatment of severe preeclampsia and Hemolysis, Elevated Liver enzymes, Low Platelets (HELLP) syndrome.

Eligibility Criteria

Age Range: 18 years to 50 years

Inclusion Criteria: * Individuals with \< 34 0/7 weeks of gestation. * Individuals with severe preeclampsia or HELLP features. Exclusion Criteria: * Pregnant female patients presenting with disseminated intravascular coagulopathy (DIC). * Individuals with non-reassuring fetal status requiring delivery, non-viable fetuses, previable pregnancy (\<23 0/7 weeks gestation), stroke, in utero fetal demise, known atypical hemolytic uremic syndrome, familial or acquired thrombocytopenia purpura, paroxysmal nocturnal hemoglobinuria, allergy to Ravulizumab, inability or unwillingness to sign informed consent.

Interventions

DRUG

Ravulizumab

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Conditions

Preeclampsia

Locations

Mayo Clinic Minnesota

Rochester, Minnesota 55905

United States