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NCT06347055NARecruitingAccepts Healthy Volunteers

NeuroControl of Nicotine Dependence

University of Missouri-Columbia

Start Date

10/1/2024

Completion Date

4/30/2030

Summary

The purpose of the study is to examine the effects of continuous theta burst stimulation (cTBS) on different forms of cognitive control in adults who smoke cigarettes, and to determine if the location where cTBS is delivered may help smokers reduce or quit smoking. Participation in the study will take 3-weeks over 4 visits, with a total time commitment of approximately 12 hours.

Eligibility Criteria

Age Range: 18 years to 60 years

Inclusion Criteria: 1. Nicotine Dependence as measured by: Smoke ≥ 8 cigarettes/day for ≥ 2 yrs, expired carbon monoxide (CO) concentration of ≥ 10 ppm, positive urine cotinine test and FTND score ≥ 3 Or ≥ 15 uses of electronic cigarette/day for ≥ 1 year, positive urine cotinine test, and PS-ECDI score ≥ 3 2. English Fluency 3. Functional Vision (with corrective lenses as needed) Exclusion Criteria: 1. Use of psychotropic and antiepileptic medications in the last month 2. Presence of an untreated illness or serious medical condition 3. History of major neurological illness 4. Contraindication to TMS (history of neurological disorder or seizure, increased intracranial pressure, brain surgery, or head trauma with loss of consciousness for \>15 min., implanted electronic device, metal in the head) or MRI. 5. Any use of substances that lower seizure threshold. 6. Current or past psychosis 7. Electroconvulsive therapy in the past 6 months 8. Unstable cardiac disease or hypertension, severe renal or liver insufficiency, or sleep apnea 9. BAC greater than 0.0. 10. Positive urine pregnancy test 11. Any other concern that in the investigator's opinion would impact participant safety, study instruction compliance, or confound the interpretation of the study results.

Interventions

DEVICE

Repetitive Transcranial Magnetic Stimulation (rTMS)

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Conditions

Nicotine Dependence

Locations

Health Neuroscience Center

Columbia, Missouri 65203

United States