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NCT06353191Recruiting

Biomarkers to Predict Cancer Therapy-related Cardiotoxicity

Mayo Clinic

Start Date

5/3/2019

Completion Date

12/31/2031

Summary

This study evaluates why some cancer patients but not others experience changes in heart function following treatment with chemotherapy.

Detailed Description

PRIMARY OBJECTIVE: I. To collect biospecimens from 1) patients who developed chemotherapy related cardiac toxicity (CRCT) and 2) patients who are at a high risk for developing CRCT. OUTLINE: This is an observational study. Patients undergo blood sample collection and have their medical records reviewed on study.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * 18 years of age or older * Treated for any malignancy with any type of chemotherapy including oral, parenteral therapy and immunotherapy * One of the following: * Diagnosed with cardiotoxicity defined as; cardiomyopathy, symptomatic heart failure, asymptomatic reduced systolic function, acute coronary syndrome, myocardial infarction, critical limb ischemia, cardiac arrhythmias or myocarditis possibly related to prior cancer treatment * Completed chemotherapy with no cardiotoxicity at least two years post treatment * Patients with cancer who will be initiating systemic therapy with potentially cardiotoxic medications. This will include chemotherapy, immunotherapy, targeted therapy that have been associated with cardiac toxicity * An understanding of the protocol and its requirements, risks, and discomforts * The ability and willingness to sign an informed consent Exclusion Criteria: \- Inability on the part of the patient to understand the informed consent or be compliant with the protocol

Interventions

OTHER

Non-Interventional Study

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Conditions

Hematopoietic and Lymphatic System NeoplasmMalignant Solid Neoplasm

Locations

Mayo Clinic in Arizona

Scottsdale, Arizona 85259

United States

Mayo Clinic in Florida

Jacksonville, Florida 32224-9980

United States

Moffitt Cancer Center

Tampa, Florida 33612

United States

Mayo Clinic in Rochester

Rochester, Minnesota 55905

United States