Investigating Micro-Manipulation Procedures for Assisted Hatching Timing
Start Date
5/31/2026
Completion Date
5/31/2028
Summary
This study aims to assess the clinical significance of cleavage stage (Day 3) assisted hatching compared to assisted hatching at the blastocyst stage (Day 5,6,7) of embryo development at the time of trophectoderm (TE) biopsy for patients undergoing in vitro fertilization (IVF) and preimplantation genetic testing for aneuploidy (PGT-A) for treatment of their infertility.
Detailed Description
The proposed study aims to perform a split cohort study where each patient's cohort of fertilized zygotes, (two pronuclei or 2PNs) is split into two groups and randomized, thus allowing each patient to serve as their own control and decreasing confounding variables. Half of the cohort will proceed with the current standard of day 3 or cleavage assisted hatching and the other half of the cohort will receive the sequential hatching and trophectoderm biopsy procedure at the blastocyst stage of embryo development.
Eligibility Criteria
Age Range: 18 years to 42 years
Interventions
Laser Assisted Hatching
Conditions
Locations
Reproductive Medicine Associates of New Jersey
Marlton, New Jersey 08053
United States