The Effects and Mechanisms of a High CBD Cannabis Extract (BRC-002) for the Treatment of Pain and Health in Complex Regional Pain Syndrome

Inclusion Criteria: 1. Provision of signed and dated informed consent form. 2. Are between 21-75 years old 3. Ability to communicate in English 4. Volunteers with no previous medical history (e.g., cardiac or pulmonary disease) 5. Are not currently using any type of cannabis, including hemp or CBD 6. Currently 30 days cannabis free 7. Participants with ongoing CRPS \[Type 1 or Type 2)\] for at least 3 months prior to participation (medical record confirmed) 8. Agrees not to use cannabis, including hemp or CBD, outside of the study during participation in the study 9. Agrees not to use opioids or barbiturates during participation in the study Exclusion Criteria: 1. Fail cannabis screening 2. Active pulmonary disease 3. Allergy or past adverse effects or negative past experiences from cannabis 4. Positive urine drug test for THC, barbiturates, opioids, oxycodone, or methadone prior to study session 1 or session 2 5. Any significant illness, including cardiovascular disease, diabetes, renal and liver disease 6. Any current or history of an immunocompromising disease or condition (such as lupus, psoriasis, multiple sclerosis, etc.) 7. Any current or history of neurologic conditions, including Parkinson disease, dementia, cognitive impairment, history of seizure disorder, and history of traumatic brain injury/head injury 8. Participant meets DSM-V criteria for current major psychiatric illness, such as bipolar disorder, major depression, psychosis, substance use disorder, or schizophrenia 9. Any current or history of suicidal ideation or attempt 10. Patients with clinically significant laboratory abnormalities