NCT06417177EARLY_PHASE1RecruitingAccepts Healthy Volunteers
Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia
University of Missouri-Columbia
Start Date
6/3/2024
Completion Date
7/1/2026
Summary
The purpose of this study is to examine hypoxic vasodilation and the role of beta-adrenergic receptors in younger premenopausal, perimenopausal, and older postmenopausal women.
Eligibility Criteria
Age Range: 18 years to 70 years
Inclusion Criteria:
* Female assigned at birth
* Pre, peri- or post-menopausal
* Healthy weight (BMI ≥18 and ≤30 kg/m2)
Exclusion Criteria:
* Male (assigned at birth)
* Pregnancy, breastfeeding
* Use of hormone replacement therapies
* Hysterectomy
* Body mass index \>30 kg/m2
* Diagnosed sleep apnea
* Current smoking/Nicotine/Drug use
* Nerve/neurologic disease
* Cardiovascular, hepatic, renal, respiratory disease
* Blood pressure ≥140/90 mmHg
* Diabetes, Polycystic ovarian syndrome
* Communication barriers
* Prescription medications
* Malignant cancer
Interventions
DRUG
Placebo
DRUG
Propranolol
DRUG
Gemtesa
Conditions
AgingMenopauseHypoxiaVasodilation
Locations
University of Missouri-Columbia
Columbia, Missouri 65211
United States