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NCT06429501PHASE2Recruiting

Local Anesthesia for Facial Fractures

Washington University School of Medicine

Start Date

4/2/2024

Completion Date

7/1/2027

Summary

The study is a double-blind randomized, placebo controlled trial examining the impact of perioperative bupivacaine nerve block on PACU recovery metrics. Patients with operative facial fractures are randomized to receive either bupivacaine or saline injections prior to the anesthesia emergence.

Detailed Description

Effective pain management is critical to successful postoperative care and is known to decrease patient morbidity, incurred patient and hospital costs, and length of hospital stay. Pain and nausea after surgery for traumatic facial fractures can limit patients' early morbidity, oral intake, and ability to communicate. The study is a double-blind randomized, placebo controlled trial examining the impact of perioperative bupivacaine nerve block on PACU recovery metrics. Patients with operative mandibular or midface fractures are randomized to receive either bupivacaine or saline injections prior to the anesthesia emergence. The primary outcome measure is the amount of opioid that patients receive in PACU in morphine milligram equivalent (MMEs). The purpose of the study is to define whether a perioperative bupivacaine nerve block results in a decrease in the amounts of opioids and antiemetics that patients receive in PACU after CMF trauma surgery.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: 1. Adults age 18 and over 2. Isolated facial fracture to the mandible and/or midface undergoing surgical repair 3. No allergy to local anesthetic 4. Ability to read, write, and understand English Exclusion Criteria: 1. Patients under the age of 18 2. Isolated nasal bone fracture 3. Polytrauma (I.e. injury pattern resulting in hospital admission for multiple bony fractures outside of the face) 4. Allergy to local anesthetic

Interventions

DRUG

Bupivacaine/Epinephrine

DRUG

Saline

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Conditions

Pain Management

Locations

Washington University

St Louis, Missouri 63110

United States