NCT06433115NARecruitingAccepts Healthy Volunteers
Effects of Lean Beef Consumption on Cardiometabolic Health and Gut Microbiome
University of Missouri-Columbia
Start Date
6/11/2024
Completion Date
12/1/2027
Summary
This study is investigating the benefits of lean beef consumption on cardiometabolic health and gut microbiome.
Detailed Description
The study is a 6-wk randomized, controlled, and parallel arm clinical trial. Participants will be randomized to consume either lean grain-fed beef, lean grass-fed beef, or plant-based meat for 6 weeks. Outcomes assessed will include metabolic, inflammatory, and gut microbiome markers.
Eligibility Criteria
Age Range: 18 years to 45 years
Inclusion Criteria:
* Age: 18-45 years of age
* BMI: 18-35 kg/m2
* Willingness to consume study foods.
* Willing to comply with study protocol.
* Consistent diet and activity patterns for 4 weeks
* Weight stable (≤5 kg change over the last 3 months)
* Non-smoker \>1 year or more
Exclusion Criteria:
* Allergies to foods provided in the study
* Diabetes
* Gastrointestinal disease and/or bariatric surgery
* Uncontrolled hypertension and blood pressure ≥ 180/110
* Illicit drug use
* Recent consumption of antibiotics or probiotics
* Recent start of medications that affect metabolism or appetite.
* Recent blood donation
* Drug therapy for coronary artery disease, peripheral artery disease, congestive - heart failure, or dyslipidemia
* Pregnant or lactating individuals
* Taste or smell disorders
* High consumers of red meat or plant-based meat (≥ 4 times/week)
Interventions
OTHER
Lean (≥90%) Grass-Fed Beef
OTHER
Lean (≥90%) Grain-Fed Beef
OTHER
Plant-Based Meat
Conditions
Diet Intervention
Locations
University of Missouri-Columbia
Columbia, Missouri 65211
United States