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NCT06433115NARecruitingAccepts Healthy Volunteers

Effects of Lean Beef Consumption on Cardiometabolic Health and Gut Microbiome

University of Missouri-Columbia

Start Date

6/11/2024

Completion Date

12/1/2027

Summary

This study is investigating the benefits of lean beef consumption on cardiometabolic health and gut microbiome.

Detailed Description

The study is a 6-wk randomized, controlled, and parallel arm clinical trial. Participants will be randomized to consume either lean grain-fed beef, lean grass-fed beef, or plant-based meat for 6 weeks. Outcomes assessed will include metabolic, inflammatory, and gut microbiome markers.

Eligibility Criteria

Age Range: 18 years to 45 years

Inclusion Criteria: * Age: 18-45 years of age * BMI: 18-35 kg/m2 * Willingness to consume study foods. * Willing to comply with study protocol. * Consistent diet and activity patterns for 4 weeks * Weight stable (≤5 kg change over the last 3 months) * Non-smoker \>1 year or more Exclusion Criteria: * Allergies to foods provided in the study * Diabetes * Gastrointestinal disease and/or bariatric surgery * Uncontrolled hypertension and blood pressure ≥ 180/110 * Illicit drug use * Recent consumption of antibiotics or probiotics * Recent start of medications that affect metabolism or appetite. * Recent blood donation * Drug therapy for coronary artery disease, peripheral artery disease, congestive - heart failure, or dyslipidemia * Pregnant or lactating individuals * Taste or smell disorders * High consumers of red meat or plant-based meat (≥ 4 times/week)

Interventions

OTHER

Lean (≥90%) Grass-Fed Beef

OTHER

Lean (≥90%) Grain-Fed Beef

OTHER

Plant-Based Meat

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Conditions

Diet Intervention

Locations

University of Missouri-Columbia

Columbia, Missouri 65211

United States