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NCT06436846RecruitingAccepts Healthy Volunteers

Genomic Risk in Retroperitoneal Sarcoma

Fox Chase Cancer Center

Start Date

3/7/2022

Completion Date

8/1/2027

Summary

The protocol intends to explore the biology which may underlie recurrences of retroperitoneal liposarcoma. Surgery remains the only curative intent intervention for this disease. Often, tumors recur in locations within the retroperitoneum remote from the original primary tumor. This study hypothesizes that normal appearing retroperitoneal fat actually harbors underlying genetic changes which predispose to development of future liposarcoma. To accomplish this goal, retroperitoneal fat is sampled from quadrants within and remote from the primary tumor and is subsequently subjected to genetic analyses looking for such predisposing factors.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Adult patients (age ≥18 years). * Histologically confirmed retroperitoneal liposarcoma via preoperative biopsy, or cross-sectional imaging suspicious for liposarcoma with planned surgical resection * Will be undergoing surgical resection for treatment of primary or recurrent disease * Have provided informed consent to participate in this study Exclusion Criteria: • Prior surgical anatomy which makes sampling of remote areas of the retroperitoneum technically impossible or clinically undesirable for safety reasons

Interventions

OTHER

Biospecimen sample collection during standard-of-care surgery

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Conditions

Retroperitoneal LiposarcomaSoft Tissue Sarcoma

Locations

Fox Chase Cancer Center

Philadelphia, Pennsylvania 19111

United States