NCT06446765PHASE2Recruiting
Mindfulness-based Neurofeedback to Augment Psychotherapy for Adults With Borderline Personality Disorder
Yale University
Start Date
3/13/2025
Completion Date
10/30/2026
Summary
The purpose of this study is to test the ability of mindfulness-based real time functional magnetic resonance imaging (fMRI) neurofeedback (mbNF) to increase the benefits of evidence-based psychotherapy for adults with Borderline Personality Disorder (BPD).
Detailed Description
The focus of this study is Aim 1.
Eligibility Criteria
Age Range: 18 years to 60 years
Inclusion criteria:
* age 18-60,
* be able to provide written informed consent,
* meet criteria for BPD on semi-structured clinical interview,
* able to plan to keep any prescribed medications and psychotherapy constant during the study
* fluent in English.
Exclusion criteria:
* current DBT psychotherapy outside the study
* lifetime primary psychotic disorder
* manic episode in the last one year
* developmental disorder (e.g. autism)
* history of learning disorder
* severe substance use disorder in the last 3 months
* active suicidal ideation with intent or plan in the past 3 months
* history of major medical or neurologic disorder
* MRI contraindications, including pregnancy
* poor performance on reading task (WRAT \> 11 errors)
* newly prescribed medications in the past 8 weeks
* daytime sedating medications (e.g. benzodiazepines, opiates, sedating neuroleptics)
* any scheduled daily benzodiazepines
* change in psychotherapy type or frequency in the past 12 weeks.
* At the discretion of the study PI
Eligibility will be determined by study personnel.
Interventions
BEHAVIORAL
mindfulness-based Neurofeedback
OTHER
control Neurofeedback
Conditions
Borderline Personality Disorder
Locations
Connecticut Mental Health Center
New Haven, Connecticut 06519
United States