Mapping of Electrical Properties in the Brain

Summary

This study evaluates imaging methods for monitoring neural and electrical activity in the brain for improving clinical diagnosis.

Detailed Description

PRIMARY OBJECTIVES: I. Optimize pulse sequence acquisitions for diffusion imaging on clinical MRI vendor systems. II. Develop image-based MRI models (including diffusion-based MRI) that accurately depict the multi-regional electrical properties in the brain (e.g., resistivity, current) to inform of neural integrity and function (including white matter tract integrity) in diseased and non-diseased states. III. Compare/correlate image-based MRI models (e.g., diffusion) with existing structural, physiologic, and functional MRI methods (e.g., tensor imaging, fMRI, DSC-MRI, etc). IV. Further train image-based models/measurements with loco-regional benchmarks including (but not exclusive to) electrophysiologic monitoring, functional and structural tissue assays (from available biopsies), and correlative clinical features (e.g., histology, outcomes, treatment, etc). OUTLINE: This is an observational study. Participants complete a survey and undergo MRI on study.

Eligibility Criteria

Interventions