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NCT06482814NARecruitingAccepts Healthy Volunteers

Sleep Restriction and Parental History of Hypertension

Mayo Clinic

Start Date

2/20/2025

Completion Date

4/1/2029

Summary

The purpose of this study is to research the effects of partial sleep deprivation (sleep restriction) in a group of individuals whose parents have high blood pressure compared to a group of individuals whose parents have normal blood pressure.

Eligibility Criteria

Age Range: 18 years to 35 years

Inclusion Criteria * Healthy adults aged 18-35 years * Absence of any significant medical or psychiatric disease (as per the investigators' judgment) * Nonsmoker * Nonpregnant * History of normal sleep duration (reported average sleep duration between 7-9 hours/night and no habitual napping) * Hypertension status information available for both biological parents * Ability to understand study procedures and to comply with them for the entire length of the study * Ability to understand English and provide informed consent Exclusion Criteria * Age \<18 or \>35 years * Body mass index \<18.5 or ≥30 kg/m2 * Pregnant or lactating * Unable to determine history of HTN in participant's biological parents or subject being adopted * Use of tobacco, vaping, marijuana products or other drugs * Excessive caffeine consumption (\>400 mg/day) * Excessive alcohol consumption (\>7 drinks/week for women, \>14 drinks/week for men) * Office SBP/DBP ≥130/80 mmHg * Daytime ambulatory SBP/DBP ≥130/80 mmHg * Fasting glucose ≥126 mg/dl * Glomerular filtration rate \<60 mL/min/BSA * History of significant medical or psychiatric disorders (as per the investigators' judgment) * Regular use of prescription medications other than contraceptives * Use of melatonin supplements or any other over-the-counter sleep aid * Moderate-to-severe sleep disordered breathing (apnea/hypopnea index, AHI ≥15) or mild sleep disordered breathing (AHI 5-15) with daytime sleepiness (Epworth Sleepiness Scale \>10) * Moderate-to-severe insomnia (Insomnia Severity Index \>14) * Restless leg syndrome (as per the Cambridge-Hopkins questionnaire) * Excessive daytime sleepiness (Epworth Sleepiness Scale \>15) * Extreme chronotype (Morningness-Eveningness Questionnaire \>69 or \<31) * Night shift work * Ongoing participation in other research studies (as per the investigators' judgment) * Any other medical, geographic, or social factor making study participation impractical * Not English-speaking and/or inability to provide informed consent * Exclusionary for blood draws: hemoglobin \<11.6 g/dL in women / \<13.2 g/dL in men; participants with measured hemoglobin levels below these thresholds will be allowed to continue participate in study tests and procedures not involving blood draws.

Interventions

BEHAVIORAL

Partial sleep deprivation (sleep restriction)

BEHAVIORAL

Normal sleep

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Conditions

Hypertension

Locations

Mayo Clinic in Rochester

Rochester, Minnesota 55905

United States