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NCT06513208PHASE4RecruitingAccepts Healthy Volunteers

Ketorolac Effects on Post-operative Pain and Lumbar Fusion

University of Maryland St. Joseph Medical Center

Start Date

1/1/2026

Completion Date

6/1/2027

Summary

A double blind prospective randomized trial of IV ketorolac vs. placebo in management of patients undergoing lumbar one or two level spinal fusions.

Eligibility Criteria

Age Range: 18 years to 85 years

Inclusion Criteria: * 18-85 years old (inclusive) * Elective posterior lumbar instrumented fusion * One or two level fusion * Consent to participate in study and willing to adhere to study follow up * English proficiency Exclusion Criteria: * \< 18 or \> 85 years old * History of renal failure, dialysis, or creatinine over 1.50 mg/dl * Active or recent smoker (active within past 6 months) * Revision surgery * Auto/worker compensation * Active cancer or history of chemotherapy in past 6 months * Active narcotic use within 3 months of surgery date * Infection at operative levels * Any allergies to NSAIDs or Opioids

Interventions

DRUG

Ketorolac Tromethamine

DRUG

Placebo

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Conditions

Lumbar Spinal Fusion

Locations

University of Maryland St. Joseph Medical Center

Towson, Maryland 21204

United States