NCT06520982EARLY_PHASE1RecruitingAccepts Healthy Volunteers
Early Neurovascular Adaptations in Aging Women
University of Missouri-Columbia
Start Date
9/20/2024
Completion Date
6/30/2028
Summary
Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.
Eligibility Criteria
Age Range: 18 years to 70 years
Inclusion Criteria:
* Assigned female at birth (AFAB)
* 18-70 years of age
Exclusion Criteria:
* Assigned male at birth (AMAB)
* Pregnancy, breastfeeding
* Body mass index ≥30 kg/m2
* Taking medications known to affect metabolic, autonomic, and/or respiratory function
* Oral hormonal contraception in last 6 month
* History of hormone replacement therapy
* History of hyster- or oophor-ectomy
* Current smoking/Nicotine use
* Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
* Chronic disease
* Blood pressure ≥140/90 mmHg
* Communication barriers
Interventions
DRUG
Norepinephrine
DRUG
Isoproterenol
DRUG
Acetylcholine
DRUG
Nitroprusside
DRUG
Estrogen
Conditions
WomenSympathetic Nervous SystemAgingBlood Flow
Locations
University of Missouri-Columbia
Columbia, Missouri 65211
United States