NCT06522880Recruiting
Cytomegalovirus (CMV) Transmission and Immune Tracking (TransmIT) Study
University of Massachusetts, Worcester
Start Date
8/10/2023
Completion Date
12/31/2027
Summary
The goal of STAGE I of the CMV TransmIT Study is to determine the prevalence of CMV shedding in children up to and including 36 months of age in large group childcare centers and in staff who regularly work at the center. Participants will complete a health survey and provide one saliva sample for CMV PCR testing. In addition, infrastructure for the study will be developed (e.g. community engagement to build the network of centers, data pipelines, digital platform, sampling workflows) and participant sample collection at home will be piloted. These activities will inform the design of STAGE II.
Eligibility Criteria
Age Range: No minimum to No maximum
Inclusion Criteria
Children
1. All children up to and including 36 months at time of signed consent regardless of duration of attendance at the center. Children living in the same household can each be enrolled.
2. Parent(s) has provided written informed consent for the child to be screened for CMV by saliva PCR collected at the center or at home
Center Staff
1. Individuals who regularly (average \>/= 5 weeks per year) work inside the center in any role, including employed, contracted, volunteer, and full or part time.
2. Staff member has provided written informed consent to be screened for CMV by saliva PCR collected at the center or at home
Exclusion Criteria
Children
1. \>/= 37 months of age
2. State Department of Children and Families (DCF) custody
Center Staff
1. Do not regularly (average \< 5 days per year) work inside the center
2. Work associated with but not regularly inside the center (e.g. bus drivers or food delivery staff)
Interventions
DIAGNOSTIC_TEST
CMV PCR on saliva
Conditions
Cytomegalovirus Infections
Locations
UMass Chan Medical School
Worcester, Massachusetts 01655
United States