NCT06536452RecruitingAccepts Healthy Volunteers

Hematopoiesis in MBL and CLL Versus Healthy Age-Matched Control Subjects

Mayo Clinic

Start Date

11/18/2016

Completion Date

11/18/2028

Summary

This study evaluates hematopoiesis to determine how MBL/CLL affected bone marrow responds to fight off infections in the body.

Detailed Description

PRIMARY OBJECTIVES: I. Determine the cellular and mechanistic basis of bone marrow (BM) hematopoietic dysfunction in untreated MBL and CLL patients. II. Determine if MBL and CLL B cell derived cellular products directly alter the differentiation and functional capacities of Hematopoietic Stem and Progenitor Cells (HSPCs). III. Utilize the Emu-Tcl1 transgenic mouse model to determine how MBL and CLL patient-derived cellular products alter BM hematopoiesis. OUTLINE: This is an observational study. Patients undergo blood sample collection and bone marrow aspiration and biopsy and have their medical records reviewed on study.

Eligibility Criteria

Age Range: 40 years to No maximum

Inclusion Criteria: * Subjects in the CLL cohort who are eligible for these studies will have a clinically established diagnosis of CLL as assessed by flow cytometry and will include subjects who * Remain untreated * Are currently being treated * Who have already been treated * Subjects in the MBL cohort will have a clinically established diagnosis of MBL * Healthy age-matched control subjects * Healthy younger control subjects aged \> 40 years Exclusion Criteria: * Anyone under 40 * Healthy control subjects must not have a diagnosis of CLL or MBL

Interventions

OTHER

Non-Interventional Study

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Conditions

Chronic Lymphocytic LeukemiaMonoclonal B-Cell Lymphocytosis

Locations

Mayo Clinic in Rochester

Rochester, Minnesota 55905

United States