NCT06614309NARecruiting
Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog
Mayo Clinic
Start Date
9/24/2024
Completion Date
12/1/2026
Summary
This study aims to assess the effects of both acute and chronic exposures to hypoxia and hypercapnia in patients with Long COVID syndrome.
Eligibility Criteria
Age Range: 18 years to No maximum
Inclusion criteria:
* English speaking
* Diagnosis of Long COVID
Exclusion criteria:
* Any history of:
* Coronary artery dissection or aortic dissection
* Neurological disease (e.g. dementia, Alzheimer's disease, or other brain-related disease)
* Cerebrovascular disease or stroke
* Aneurysm
* If currently has:
* Moderate-severe chronic obstructive pulmonary disease
* Uncontrolled moderate-severe asthma
* Moderate-severe bronchiectasis
* Moderate-severe interstitial lung disease, requiring the use of supplemental oxygen
* A necessity to use supplemental oxygen, for any reason
* New or worsening symptoms (decompensation) of heart failure
* Right heart disease due to chronic pulmonary disease/sleep apnea
* Uncontrolled myocardial ischemia or angina
* Uncontrolled heart arrhythmias
* Heart or lung infection (e.g. myocarditis or pericarditis)
* Left main coronary artery stenosis
* Moderate-severe aortic stenosis
* Pulmonary embolism, pulmonary infarction, or other blood clots
* Severe respiratory disease
* Chronic kidney disease
* Chronic liver disease
* Females of childbearing potential will complete a urine pregnancy test at their baseline visit to rule out pregnancy
* BMI \>40
* Study staff unable to obtain adequate signal for cerebral blood flow
Interventions
OTHER
Acute Placebo Visit
OTHER
Acute Progressive Carbon Dioxide
OTHER
Acute Intermittent Hypoxia
OTHER
Training: Progressive Carbon Dioxide Ramping
OTHER
Training: Intermittent Hypoxic Exposure
OTHER
Training: Placebo Control
Conditions
Long COVID
Locations
Mayo Clinic in Arizona
Scottsdale, Arizona 85259
United States