NCT06641297NARecruiting
White Matter Plasticity in Schizophrenia
University of Maryland, Baltimore
Start Date
1/2/2025
Completion Date
12/31/2026
Summary
Schizophrenia spectrum disorders are associated with impairment in the microstructure of white matter, the key brain tissue responsible for fast communication between different brain regions necessary for any complex task. This white matter impairment is linked to problems with cognition in schizophrenia, especially slower processing speed. This project aims to study the potential for correcting white matter deficits in schizophrenia by examining mechanisms underlying white matter structure changes in response to training on playing a mock musical instrument.
Eligibility Criteria
Age Range: 15 years to 45 years
Inclusion Criteria:
* Diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, or psychosis NOS
* age 15-45
* able to provide informed consent
Exclusion Criteria:
* contraindications to MRI (metal implants, claustrophobia)
* medical condition that limits use of hands (ie, arthritis)
* Active or recent (within 6 months) substance use disorder other than nicotine
Interventions
BEHAVIORAL
Music video game
Conditions
Schizophrenia Disorders
Locations
Maryland Psychiatric Research Center
Catonsville, Maryland 21228
United States
University of Maryland Baltimore - Maryland Psychiatric Research Center
Catonsville, Maryland 21228
United States