A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).
Start Date
2/25/2025
Completion Date
9/5/2031
Summary
The Purpose of the Study is to Compare the Efficacy and Safety of BMS-986489 (Anti-fucosyl-GM1+ Nivolumab Fixed Dose Combination) in Combination with Carboplatin plus Etoposide to that of Atezolizumab with Carboplatin plus Etoposide as First-Line Therapy in Participants with Extensive-Stage Small Cell Lung Cancer.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
BMS-986489 (BMS-986012+Nivolumab)
Atezolizumab
Carboplatin
Etoposide
Conditions
Locations
Southern Cancer Center, PC
Daphne, Alabama 36526
United States
Local Institution - 0283
Hot Springs, Arkansas 71913
United States
Florida Cancer Specialists - South
Fort Myers, Florida 33901
United States
Mid Florida Hematology and Oncology Center
Orange City, Florida 32763
United States
Florida Cancer Specialists - North
St. Petersburg, Florida 33705
United States
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital
Marietta, Georgia 30060
United States
Illinois Cancer Care
Peoria, Illinois 61615
United States
Local Institution - 0037
Minneapolis, Minnesota 55407
United States
University of New Mexico Comprehensive Cancer Center
Albuquerque, New Mexico 87106
United States
Duke Cancer Institute
Durham, North Carolina 27710
United States
Sanford Medical Center
Bismarck, North Dakota 58501
United States
Sanford Fargo Medical Center
Fargo, North Dakota 58102
United States
Oncology Hematology Care
Cincinnati, Ohio 45242
United States
Sanford Cancer Center
Sioux Falls, South Dakota 57104
United States
SCRI Oncology Partners
Nashville, Tennessee 37203
United States
Texas Oncology - Central/South Texas
Austin, Texas 78705
United States
Texas Oncology - Northeast Texas
Tyler, Texas 75702
United States
Oncology & Hematology Associates of Southwest Virginia, Inc.
Roanoke, Virginia 24014
United States
Swedish Cancer Institute - Edmonds
Edmonds, Washington 98026
United States
Swedish Medical Center
Seattle, Washington 98104
United States
Local Institution - 0079
Ciudad Autónoma de Buenos Aires, Buenos Aires C1426ANZ
Argentina
Local Institution - 0077
ABB, Buenos Aires F.D. C1199ABB
Argentina
Local Institution - 0100
Buenos Aires, Buenos Aires F.D. C1417DTB
Argentina
Local Institution - 0080
CABA, Buenos Aires F.D. C1430EGF
Argentina
Local Institution - 0094
Río Cuarto, Córdoba Province X5800AEV
Argentina
Local Institution - 0202
Campbelltown, New South Wales 2560
Australia
Local Institution - 0106
Penrith, New South Wales 2750
Australia
Local Institution - 0105
Brisbane, Queensland 4120
Australia
Local Institution - 0190
Ballarat Central, Victoria 3350
Australia
Local Institution - 0175
Murdoch, Western Australia 6150
Australia
Local Institution - 0253
Graz, Styria 8036
Austria
Local Institution - 0251
Wels, Upper Austria 4600
Austria
Local Institution - 0252
Linz, 4021
Austria
Local Institution - 0255
Rankweil, 6830
Austria
Local Institution - 0198
Brussels, Bruxelles-Capitale, Région de 1200
Belgium
Local Institution - 0091
Ghent, Oost-Vlaanderen 9000
Belgium
Local Institution - 0187
Sint-Niklaas, Oost-Vlaanderen B-9100
Belgium
Local Institution - 0092
Liège, 4000
Belgium
Local Institution - 0166
Fortaleza, Ceará 60135-237
Brazil
Local Institution - 0165
Porto Alegre, Rio Grande do Sul 90035-903
Brazil
Local Institution - 0169
Porto Alegre, Rio Grande do Sul 90610-000
Brazil
Local Institution - 0170
Santa Cruz do Sul, Rio Grande do Sul 96830-180
Brazil
Local Institution - 0163
Itajaí, Santa Catarina 88301-220
Brazil
Local Institution - 0178
Barretos, São Paulo 14784400
Brazil
Local Institution - 0111
São Paulo, São Paulo 01509-010
Brazil
Local Institution - 0289
Edmonton, Alberta T6G 1Z2
Canada
Local Institution - 0290
Chicoutimi, Quebec G7H 5H6
Canada
Local Institution - 0288
Québec, Quebec G1V 4G5
Canada
Local Institution - 0287
Rimouski, Quebec G5L 5T1
Canada
Local Institution - 0086
Santiago, Santiago Metropolitan 0
Chile
Local Institution - 0085
Santiago, Santiago Metropolitan 7500921
Chile
Local Institution - 0083
Santiago, Santiago Metropolitan 8330032
Chile
Local Institution - 0084
Santiago, Santiago Metropolitan 8420383
Chile
Local Institution - 0082
Viña del Mar, Valparaiso 2520598
Chile
Local Institution - 0204
Beijing, Beijing Municipality 100142
China
Local Institution - 0336
Beijing, Beijing Municipality 101149
China
Local Institution - 0203
Chongqing, Chongqing Municipality 400030
China
Local Institution - 0308
Fuzhou, Fujian 350014
China
Local Institution - 0212
Xiamen, Fujian 361003
China
Local Institution - 0234
Shantou, Guangdong 515000
China
Local Institution - 0227
Harbin, Heilongjiang 150081
China
Local Institution - 0209
Wuhan, Hubei 430079
China
Local Institution - 0208
Wuhan, Hubei 430100
China
Local Institution - 0216
Changsha, Hunan 410013
China
Local Institution - 0233
Nanchang, Jiangxi 330006
China
Local Institution - 0244
Changchun, Jilin 132000
China
Local Institution - 0235
Shenyang, Liaoning 110042
China
Local Institution - 0335
Xi'an, Shaanxi 710126
China
Local Institution - 0200
Jinan, Shandong 250117
China
Local Institution - 0206
Shanghai, Shanghai Municipality 200030
China
Local Institution - 0210
Shanghai, Shanghai Municipality 200032
China
Local Institution - 0186
Shanghai, Shanghai Municipality 200120
China
Local Institution - 0330
Chengdu, Sichuan 610041
China
Local Institution - 0213
Tianjin, Tianjin Municipality 300060
China
Local Institution - 0236
Hangzhou, Zhejiang 310016
China
Local Institution - 0237
Hangzhou, Zhejiang 310022
China
Local Institution - 0229
Linhai, Zhejiang 317000
China
Local Institution - 0114
Brno, Brno-město 656 53
Czechia
Local Institution - 0117
Ostrava, Ostrava Město 703 00
Czechia
Local Institution - 0113
Prague, Praha 4 14059
Czechia
Local Institution - 0116
Olomouc, 779 00
Czechia
Local Institution - 0048
Montpellier, Hérault 34090
France
Local Institution - 0040
La Tronche, Isère 38700
France
Local Institution - 0052
Lille, Nord 59037
France
Local Institution - 0044
Gleizé, Rhône 69400
France
Local Institution - 0051
Pierre-Bénite, Rhône 69310
France
Local Institution - 0047
Créteil, Val-de-Marne 94010
France
Local Institution - 0038
Villejuif, Val-de-Marne 94800
France
Local Institution - 0043
Marseille, 13915
France
Local Institution - 0050
Paris, 75248
France
Local Institution - 0215
Quimper, 29000
France
Local Institution - 0256
Frankfurt am Main, Hesse 60488
Germany
Local Institution - 0262
Oldenburg, Lower Saxony 26121
Germany
Local Institution - 0261
Cologne, North Rhine-Westphalia 51109
Germany
Local Institution - 0265
Halle, Saxony-Anhalt 06120
Germany
Local Institution - 0257
Bad Berka, Thuringia 99437
Germany
Local Institution - 0258
Gauting, 82131
Germany
Local Institution - 0259
Großhansdorf, 22927
Germany
Thoraxklinik-Heidelberg gGmbH
Heidelberg, 69126
Germany
Local Institution - 0264
Stuttgart, 70736
Germany
Local Institution - 0063
Athens, Attikí 115 26
Greece
Local Institution - 0064
Athens, Attikí 115 27
Greece
Local Institution - 0062
Thessaloniki, Kentrikí Makedonía 540 07
Greece
Local Institution - 0058
Thessaloniki, Thessaloníki 570 01
Greece
Local Institution - 0059
Larissa, Thessalía 41110
Greece
Local Institution - 0274
Bengaluru, Karnataka 560017
India
Local Institution - 0278
New Delhi, National Capital Territory of Delhi 110029
India
Local Institution - 0271
Madurai, Tamil Nadu 625107
India
Local Institution - 0277
Varanasi, Uttar Pradesh 221005
India
Local Institution - 0273
Kolkata, West Bengal 700094
India
Local Institution - 0072
Naples, Campania 80131
Italy
Local Institution - 0068
Milan, Lombardy 20133
Italy
Local Institution - 0069
Rome, Roma 00144
Italy
Local Institution - 0110
Perugia, Umbria 06132
Italy
Local Institution - 0070
Peschiera del Garda, Verona 37019
Italy
Local Institution - 0074
Bologna, 40138
Italy
Local Institution - 0067
Milan, 20141
Italy
Local Institution - 0319
Matsuyama, Ehime 791-0280
Japan
Local Institution - 0292
Kurume, Fukuoka 830-0011
Japan
Local Institution - 0313
Sapporo, Hokkaido 0608648
Japan
Local Institution - 0323
Kobe, Hyōgo 650-0047
Japan
Local Institution - 0321
Kanazawa, Ishikawa-ken 920-8641
Japan
Local Institution - 0316
Yokohama, Kanagawa 236-0051
Japan
Local Institution - 0291
Sendai, Miyagi 9810914
Japan
Local Institution - 0324
Kashihara, Nara 634-8522
Japan
Local Institution - 0328
Kurashiki, Okayama-ken 710-8602
Japan
Local Institution - 0317
Hirakata, Osaka 573-1191
Japan
Local Institution - 0314
Ōsaka-sayama, Osaka 589-8511
Japan
Local Institution - 0325
Takatsuki, Osaka 569-8686
Japan
Local Institution - 0320
Hidaka, Saitama 350-1298
Japan
Local Institution - 0318
Ina-machi, Saitama 362-0806
Japan
Local Institution - 0322
Hamamatsu, Shizuoka 431-3192
Japan
Local Institution - 0326
Bunkyo-ku, Tokyo 1138603
Japan
Local Institution - 0315
Koto, Tokyo 135-8550
Japan
Local Institution - 0327
Fukushima, 960-1295
Japan
Hospital Kuala Lumpur
Kuala Lumpur, Kuala Lumpur 50586
Malaysia
Local Institution - 0312
Kuala Lumpur, Kuala Lumpur 50603
Malaysia
Local Institution - 0311
Kuching, Sarawak 93586
Malaysia
Local Institution - 0146
Guadalajara, Jalisco 44630
Mexico
Local Institution - 0145
Puebla City, 72424
Mexico
Local Institution - 0097
Amsterdam, North Holland 1081 HV
Netherlands
Local Institution - 0099
Arnhem, 6815 AD
Netherlands
Local Institution - 0098
Groningen, 9713 GZ
Netherlands
Local Institution - 0193
Konin, Greater Poland Voivodeship 62-500
Poland
Local Institution - 0241
Poznan, Greater Poland Voivodeship 60-192
Poland
Local Institution - 0192
Prabuty, Pomeranian Voivodeship 82-550
Poland
Local Institution - 0195
Bydgoszcz, 85796
Poland
Local Institution - 0189
Lodz, Łódź Voivodeship 93-338
Poland
Local Institution - 0133
Bucharest, Bucharest 013812
Romania
Local Institution - 0135
Bucharest, Bucharest 022328
Romania
Local Institution - 0137
Florești, Cluj 407280
Romania
Local Institution - 0140
Craiova, Dolj 200542
Romania
Local Institution - 0141
Cluj-Napoca, 400015
Romania
S.C. Centrul de Oncologie Euroclinic S.R.L.
Iași, 700106
Romania
Institutul Regional de Oncologie
Iași, 700483
Romania
Local Institution - 0305
Cheongju-si, Chungcheongbuk-do [Chungbuk] 28644
South Korea
Local Institution - 0286
Seongnam, Kyǒnggi-do 13620
South Korea
Local Institution - 0304
Suwon, Kyǒnggi-do 16499
South Korea
Local Institution - 0285
Seoul, Seoul-teukbyeolsi [Seoul] 03722
South Korea
Local Institution - 0293
Seoul, Seoul-teukbyeolsi [Seoul] 05505
South Korea
Local Institution - 0309
Daegu, Taegu-Kwangyǒkshi 42601
South Korea
Local Institution - 0300
Santiago de Compostela, A Coruña [La Coruña] 15706
Spain
Local Institution - 0294
Barcelona, Catalunya [Cataluña] 08036
Spain
Local Institution - 0302
Barcelona, Catalunya [Cataluña] 08041
Spain
Local Institution - 0301
Jaén, Jaén 23007
Spain
Local Institution - 0298
Madrid, Madrid, Comunidad de 28034
Spain
Local Institution - 0296
Madrid, Madrid, Comunidad de 28041
Spain
Local Institution - 0297
Majadahonda, Madrid, Comunidad de 28222
Spain
Local Institution - 0303
Valencia, Valenciana, Comunitat 46014
Spain
Local Institution - 0299
Seville, 41009
Spain
Local Institution - 0295
Seville, 41013
Spain
Local Institution - 0248
Chur, 7000
Switzerland
Local Institution - 0249
Winterthur, 8401
Switzerland
Local Institution - 0247
Zurich, 8091
Switzerland
Local Institution - 0158
Çiğli, İzmir 35620
Turkey (Türkiye)
Local Institution - 0154
Adana, 01370
Turkey (Türkiye)
Local Institution - 0157
Ankara, 06010
Turkey (Türkiye)
Local Institution - 0177
Ankara, 06280
Turkey (Türkiye)
Local Institution - 0153
Istanbul, 34732
Turkey (Türkiye)
Local Institution - 0183
Central Middlesbrough, Middlesbrough TS4 3BW
United Kingdom
Local Institution - 0159
Aberdeen, AB9 2ZB
United Kingdom
Local Institution - 0101
Manchester, M20 4BX
United Kingdom
Local Institution - 0226
Metropolitan Borough of Wirral, CH63 4JY
United Kingdom