NCT06651333Recruiting
fMRI and Opioid Abstinence
Yale University
Start Date
12/12/2024
Completion Date
11/1/2029
Summary
This project examines functional connectivity patterns associated with subsequent relapse to illicit opioids during treatment for OUD.
Eligibility Criteria
Age Range: 18 years to 50 years
Inclusion Criteria:
* recent initiation of methadone or buprenorphine at a clinic or program within the past year (i.e., period of time during which treatment drop-out and risk for relapse is highest);
* eligibility for MRI scanning;
* ability to commit to study visits.
Exclusion Criteria:
* current acute psychosis, mania, or suicidal ideation with intent, as assessed during screening with the SCID-5;
* current intoxication or acute withdrawal at time of study visit sufficient to prevent participation based on: behavioral observation, breathalyzer, and SOWS assessment;
* severe cognitive impairment as determined via trained clinical research staff through consent process and during consent quiz or as indicated by a PROMIS Cognitive Function tscore \<30 (i.e., severe impairment)
* past or present history of intellectual disability, developmental disorder, or neurological disease;
* head trauma with loss of consciousness \>30 min;
* organ dysfunction or any unstable or untreated medical conditions that may interfere with study participation.
Interventions
DIAGNOSTIC_TEST
fMRI
Conditions
Drug Use DisorderOpioid DependenceOpioid-Related DisordersOpioid UseOpioid Abuse
Locations
The APT Foundation
New Haven, Connecticut 06520
United States