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NCT06651333Recruiting

fMRI and Opioid Abstinence

Yale University

Start Date

12/12/2024

Completion Date

11/1/2029

Summary

This project examines functional connectivity patterns associated with subsequent relapse to illicit opioids during treatment for OUD.

Eligibility Criteria

Age Range: 18 years to 50 years

Inclusion Criteria: * recent initiation of methadone or buprenorphine at a clinic or program within the past year (i.e., period of time during which treatment drop-out and risk for relapse is highest); * eligibility for MRI scanning; * ability to commit to study visits. Exclusion Criteria: * current acute psychosis, mania, or suicidal ideation with intent, as assessed during screening with the SCID-5; * current intoxication or acute withdrawal at time of study visit sufficient to prevent participation based on: behavioral observation, breathalyzer, and SOWS assessment; * severe cognitive impairment as determined via trained clinical research staff through consent process and during consent quiz or as indicated by a PROMIS Cognitive Function tscore \<30 (i.e., severe impairment) * past or present history of intellectual disability, developmental disorder, or neurological disease; * head trauma with loss of consciousness \>30 min; * organ dysfunction or any unstable or untreated medical conditions that may interfere with study participation.

Interventions

DIAGNOSTIC_TEST

fMRI

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Conditions

Drug Use DisorderOpioid DependenceOpioid-Related DisordersOpioid UseOpioid Abuse

Locations

The APT Foundation

New Haven, Connecticut 06520

United States