Effect of Adding Glycerol to Electrolyte Beverages on Fluid Balance in Healthy Euhydrated Men and Women at Rest
Start Date
9/30/2024
Completion Date
5/30/2025
Summary
The results of a prior study PEP-2311 suggested there was a positive dose-response effect of glycerol and sodium on fluid balance and fluid retention. In addition, inclusion of glycerol resulted in an upward shift in the relationship between sodium concentration and fluid balance. The practical interpretation is that addition of glycerol enables a reduction in sodium concentration compared with a 0% glycerol drink. In this follow-up study, the investigators hypothesize that 1) fluid balance will be sustained (greater than or not different from baseline) and significantly greater than placebo for 120 min after drinking the test no/low/moderate carbohydrate beverages and 2) fluid balance will not differ between the carbohydrate-electrolyte beverages, but both will be greater than placebo.
Detailed Description
This is a two-part study. Subjects will be asked to complete either Part 1 or Part 2 of this study. Subjects can participate in both parts of the study if they are interested and available to complete all trials. However, they will be asked to complete Part 1 before enrolling in Part 2 of the study. Dosing days are separated by 2-15 days. Objective 1) To compare the effect of consumption of four no/low/moderate carbohydrate drinks with high electrolyte concentrations vs. placebo on fluid balance at rest. To enroll N=25 Objective 2) To compare the effect of consumption of two moderate carbohydrate drinks with low electrolyte concentrations vs. placebo on fluid balance at rest. To enroll N=70
Eligibility Criteria
Age Range: 18 years to 50 years
Interventions
Placebo beverage, kiwi-strawberry flavor (Part 1 and Part 2)
0% carbohydrate electrolyte solution with glycerol beverage (Part 1 only)
0% carbohydrate electrolyte solution without glycerol beverage (Part 1 only)
1% carbohydrate electrolyte solution with glycerol beverage (Parts 1 and 2)
6% carbohydrate electrolyte solution with glycerol beverage (Parts 1 and 2)
6% carbohydrate electrolyte solution without glycerol beverage (Part 2 only)
2% carbohydrate electrolyte solution without glycerol beverage (Part 2 only)
Conditions
Locations
PepsiCo R&D, Gatorade Sports Science Institute
Valhalla, New York 10595
United States