NCT06665295NARecruiting

THRIVE-CAR-T Digital App

Patrick C. Johnson, MD

Start Date

10/17/2024

Completion Date

12/31/2026

Summary

The goal of this clinical trial is to learn if a digital mobile application called THRIVE-CAR-T is helpful for the care of patients undergoing CAR-T cell therapy. The main question\[s\] it aims to answer are whether the THRIVE-CAR-T app is feasible and acceptable to patients.

Detailed Description

This pilot randomized controlled trial aims to examine the feasibility, acceptability, and preliminary effects of a supportive care digital app (THRIVE-CAR-T) versus usual care in patients receiving chimeric antigen receptor T-cell therapy (CAR-T). The primary objective of the study is to determine if THRIVE-CAR-T is feasible and acceptable to patients. The exploratory objective is to assess the preliminary effects of THRIVE-CAR-T for improving patient-reported quality of life (QOL), psychological distress, and self efficacy.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: 1. Age 18 years or older 2. Ability to understand English 3. Diagnosis of a hematologic malignancy 4. Receiving autologous CAR-T at MGH with an FDA approved cellular therapy product Exclusion Criteria: 1. Impaired cognition or uncontrolled mental illness that prohibits the ability to provide informed consent based on the oncology clinician assessment 2. Already participating in another supportive care clinical trial

Interventions

BEHAVIORAL

THRIVE-CAR-T

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Conditions

CAR T-Cell Therapy

Locations

Massachusetts General Hospital

Boston, Massachusetts 02114

United States