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NCT06670079NARecruiting

Prolonged Exposure Therapy to Treat Posttraumatic Stress Disorder in Pregnant Patients

University of Vermont

Start Date

2/5/2026

Completion Date

7/22/2027

Summary

The goal of this clinical trial is to learn if a treatment for adults with PTSD called prolonged exposure + incentives (PE+) works to treat pregnant patients. The main question it aims to answer is: Does PE+ decrease PTSD symptoms? All participants will receive PE+ to see if their PTSD symptoms at the end of the trial are less than at the beginning. Participants will: * Receive individual PE+ therapy for 1 hour weekly for 12 weeks. * Receive financial incentives for attending each PE+ session. * Attend assessment visits every 4 weeks for the 12 weeks of the trial. * Allow research staff to collect some information about their labor and delivery from their medical records after their babies are born.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Female * \>18 years old * Gestational age ≤ 25 weeks * Meet current DSM-5 posttraumatic stress disorder criteria based on the Clinician Administered PTSD Scale for DSM-5 * Participants receiving psychotropic medications must be maintained on a stable dose for \>14 days prior to enrollment. Exclusion Criteria: * Male * Under 18 years old * Gestational age \> 25 weeks * No current diagnosis of PTSD * Current delusions or hallucinations, unstable bipolar disorder, imminent risk for suicide as assessed by the Mini International Neuropsychiatric Interview * Enrolled in another ongoing evidence-based treatment for PTSD.

Interventions

BEHAVIORAL

Prolonged exposure therapy + incentives for therapy session attendance

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Conditions

Posttraumatic Stress DisorderPregnancy

Locations

University of Vermont

Burlington, Vermont 05401

United States