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NCT06678659PHASE1, PHASE2Recruiting

A Study of REC-1245 in Participants With Unresectable, Locally Advanced, or Metastatic Cancer

Recursion Pharmaceuticals Inc.

Start Date

11/21/2024

Completion Date

10/30/2028

Summary

This is a multi-center, open-label study to investigate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary activity of REC-1245 administered orally on a once daily (QD) schedule in participants with unresectable, locally advanced, or metastatic solid tumors.

Detailed Description

The purpose of this study is to investigate the safety, tolerability and pharmacokinetics of REC-1245 for the treatment of participants with unresectable locally advanced or metastatic solid tumors. Participants will receive treatment with REC-1245 for up to 2 years.

Eligibility Criteria

Age Range: 12 years to No maximum

Inclusion Criteria: * Have histologically-confirmed unresectable, locally advanced, or metastatic select solid tumors or select relapsed / refractory lymphoma * Have experienced progressive disease, relapsed disease, or be intolerant to at least one established standard systemic anti-cancer treatment for a given tumor type, or have been considered ineligible for standard therapy. * Eastern cooperative oncology group (ECOG) performance status ≤1; for adolescent participants, Lansky Performance Status Scale or Karnofsky Performance Status Scale score of ≥70. * Measurable disease at baseline per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 / Lugano criteria and documented by computed tomography (CT) and / or magnetic resonance imaging (MRI) Exclusion Criteria: * Received treatment with another RBM39 degrader * Clinically significant gastrointestinal (GI) or GI malabsorption

Interventions

DRUG

REC-1245

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Conditions

UnresectableLocally AdvancedMetastatic CancersRelapsed/Refractory Lymphomas

Locations

City of Hope

Duarte, California 91010

United States

Cleveland Clinic

Cleveland, Ohio 44195

United States

SCRI Oncology Partners - PPDS

Nashville, Tennessee 37203

United States

START Mountain Region

West Valley City, Utah 84119

United States

Princess Margaret Cancer Centre

Toronto, Ontario M5G 1X6

Canada

McGill University Health Centre (MUHC) - The Montreal

Québec, H4A3J1

Canada