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NCT06686914PHASE1RecruitingAccepts Healthy Volunteers

The Effects of Cannabidiol on the Driving Performance of Healthy Adults by Dose and Sex

West Virginia University

Start Date

6/30/2025

Completion Date

5/1/2029

Summary

The objectives/purpose of this study are to comprehensively investigate the effects of non-prescription CBD on driving performance, drowsiness, sedation, and cognitive function in a large sample of healthy adults aged 18-30 years, with additional characterization of effects by dose and by sex, using a rigorous RCT design which will naturally mitigate confounding factors.

Eligibility Criteria

Age Range: 18 years to 30 years

Inclusion Criteria: * Possess a current drivers' license * Driven a motor vehicle at least once in the past 30 days * Able to read English * Test negative for all substances on a urine drug test and complete a test drive to ensure the absence of simulation sickness * Not taking any daily prescription medications (excluding birth control) * Not diagnosed with any serious chronic disease by a licensed healthcare provider (including but not limited to Alzheimer's and related dementias, Parkinson's disease or other neurodegenerative disorder, major depressive or anxiety disorder, schizophrenia or other serious mental illness, arrhythmias, cataracts, glaucoma, chronic obstructive pulmonary disease, diabetes, epilepsy, sleep apnea, and fibromyalgia) * Have an individual willing to drive them home after testing or be taken home by study staff after testing Exclusion Criteria: * Currently smoke, vape or use tobacco products, used CBD in the past 30 days * Used illegal drugs in the past 30 days (e.g., cocaine/crack, heroin, methamphetamine, 3,4-methylenedioxy-methamphetamine, inhalants, phencyclidine, lysergic acid diethylamide, psilocybin mushrooms, or marijuana) * Are pregnant or lactating at time of study

Interventions

DRUG

Cannabidiol (CBD) Oil 300mg

DRUG

Cannabidiol (CBD) Oil 150mg

DRUG

Placebo Oil

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Conditions

Cannabidiol EffectsDriving Performance

Locations

West Virginia University

Morgantown, West Virginia 26506

United States