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NCT06697197PHASE1, PHASE2Recruiting

A Study of BMS-986482 Alone or as Combination Therapy in Participants With Advanced Solid Tumors

Bristol-Myers Squibb

Start Date

2/17/2025

Completion Date

1/5/2029

Summary

The purpose of this study is to test the safety and efficacy of BMS-986482 alone and as combination therapy in participants with advanced solid tumors.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * All participants must have a histologically or cytologically confirmed, advanced, unresectable/metastatic, solid malignancy measurable by RECIST v1.1, and have received, be refractory to, ineligible for, intolerant of, or refused existing therapy(ies) known to provide clinical benefit for the condition of the participant. * Participant must be ≥ 18 years or the legal age of consent in the jurisdiction in which the study is taking place, inclusive, at the time of signing the ICF. Exclusion Criteria: * History of life threatening immune mediated toxicity related to prior T-cell agonist or checkpoint inhibitor therapy, except those that are unlikely to re-occur with standard countermeasures. * Any significant acute or chronic medical illness which would interfere with study intervention or follow-up in the opinion of the investigator. * Other protocol-defined Inclusion/Exclusion criteria apply.

Interventions

DRUG

BMS-986482

DRUG

Nivolumab and rHuPH20

DRUG

Nivolumab/relatlimab/rHuPH20

DRUG

Bevacizumab

Interested in This Trial?

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Conditions

Advanced Solid Tumors

Locations

University of California, Irvine (UCI) Health - UC Irvine Medical Center

Irvine, California 92612

United States

The Angeles Clinic and Research Institute - West Los Angeles Office

Los Angeles, California 90025

United States

Local Institution - 0008

Aurora, Colorado 80045

United States

John Theurer Cancer Center at Hackensack University Medical Center

Hackensack, New Jersey 07601

United States

Northwell Health/ RJ Zuckerberg Cancer Center

Lake Success, New York 11042

United States

Levine Cancer Institute

Charlotte, North Carolina 28204

United States

Fred Hutchinson Cancer Center

Seattle, Washington 98109

United States

UZ Gent

Ghent, Oost-Vlaanderen 9000

Belgium

Rigshospitalet

Copenhagen, Capital Region DK-2100

Denmark

Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone

Marseille, Bouches-du-Rhône 13385

France

Gustave Roussy

Villejuif, Paris 94800

France

General Hospital of Athens "Laiko"

Athens, Attikí 11527

Greece

Papageorgiou General Hospital of Thessaloniki

Thessaloniki, Thessaloníki 564 29

Greece

Fondazione IRCCS Istituto Nazionale dei Tumori

Milan, Lombardy 20133

Italy

Istituto Clinico Humanitas

Rozzano, Milano 20089

Italy

Nederlands Kanker Instituut Antoni van Leeuwenhoek (NKI AVL)

Amsterdam, North Holland 1066 CX

Netherlands

Erasmus Medisch Centrum

Rotterdam, 3015 GD

Netherlands

Hospital Universitari Vall d'Hebron

Barcelona, Barcelona [Barcelona] 08035

Spain

Clinica Universidad de Navarra

Pamplona, Navarre 31008

Spain

Hospital Universitario HM Sanchinarro

Madrid, 28050

Spain

Karolinska Universitetssjukhuset Solna

Solna, Stockholms Län [se-01] 171 64

Sweden