Back to Trials
NCT06703476PHASE3Recruiting

A Study of Surgical Techniques During Cystectomy

Memorial Sloan Kettering Cancer Center

Start Date

11/21/2024

Completion Date

11/1/2028

Summary

The purpose of this study is to look at two standard surgical techniques used during a radical cystectomy and see whether they influence outcomes such as length of stay in the hospital and infections after surgery. This trial will evaluate whether the following surgical methods influence outcomes: A ureteral stent is a thin tube that is placed in the ureter to drain urine from the kidney. Ureteral stents are often used to promote urine drainage after radical cystectomy, but may come at risk of urinary tract infection. Alvimopan is a standard drug used to promote return of bowel function following surgery. Doctors do not know whether alvimopan is beneficial in current clinical practice. The surgeon will decide whether participants will receive a stent and/or alvimopan, but if they are unsure what the best approach is, a surgical technique has been assigned by chance to them.

Eligibility Criteria

Age Range: 21 years to No maximum

Inclusion Criteria: Stent vs. no stent * Patients aged ≥21 years who are scheduled to undergo radical cystectomy for treatment of bladder cancer with one of the consenting surgeons Alvimopan vs. no alvimopan * Patients aged ≥21 years who are scheduled to undergo radical cystectomy for treatment of bladder cancer with one of the consenting surgeons Exclusion Criteria: Stent vs. no stent * No exclusion criteria Alvimopan vs. no alvimopan * Patients on chronic opioid therapy are ineligible to receive alvimopan and will be excluded from this cohort of the trial

Interventions

PROCEDURE

Stent placement

DRUG

Alvimopan

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

Bladder Cancer

Locations

Memorial Sloan Kettering at Basking Ridge (Consent Only)

Basking Ridge, New Jersey 07920

United States

Memorial Sloan Kettering Monmouth (Consent Only)

Middletown, New Jersey 07748

United States

Memorial Sloan Kettering Bergen (Consent Only)

Montvale, New Jersey 07645

United States

Memorial Sloan Kettering Suffolk-Commack (Consent Only)

Commack, New York 11725

United States

Memorial Sloan Kettering Westchester (Consent Only)

Harrison, New York 10604

United States

Memorial Sloan Kettering Cancer Center (All Protocol Activites)

New York, New York 10065

United States

Memorial Sloan Kettering Nassau (Consent Only)

Rockville Centre, New York 11553

United States